ALCOHOLIC LIVER PATHOLOGY: HEPATIC CEREBRAL INTERACTION

拟议的研究调查了潜在的机制 神经功能障碍与社会适应和角色表现 在酗酒者身上。具体来说，肝脏的类型和严重程度 将对酗酒者的疾病进行组织学和 生化的关于大小和具体表现的 神经心理测试测量的神经功能缺陷，临床 神经学检查，在部分病例中，通过磁学检查 磁共振成像。这些研究将澄清在何种程度上 一种肝性脑病及其特殊的内在病理 肝脏疾病的伴发疾病决定了神经后遗症 酗酒。 第二项研究将评估原位肝移植的效果。 移植在神经功能损害修复中的作用 改善酗酒者的心理社会适应。这些 结果将提供重要的新信息， 酒精性肝病的协同医疗管理可以增加 酗酒者的康复。

The proposed research investigate the mechanisms underlying neurologic impairment and social adjustment and role performance in alcoholics. Specifically, the type and severity of liver disease in alcoholics will be evaluated histologically and biochemically with respect to magnitude and specific manifestation of neurologic deficit measured by neuropsychological test, clinical neurologic examination and in a subset of cases, by magnetic resonance imaging. These studies will clarify the extent to which an hepatic encephalopathy and the particular intrinsic pathologic concomitants of hepatic disease determine the neurologic sequelae of alcoholism. A second study will evaluate the effects of orthotopic hepatic transplantation on recovery of neurologic impairment and improvement in psychosocial adjustment of alcoholics. These results will provide important new information regarding whether concerted medical management of alcoholic liver disease can augment the rehabilitation of alcoholics.