ALCOHOLIC LIVER PATHOLOGY: HEPATIC CEREBRAL INTERACTION

六组受试者包括：1）无肝病的酗酒者; 2)酒精中毒性脂肪肝（脂肪变性）或纤维化; 3）酒精中毒性脂肪肝 肝硬化伴或不伴肝炎; 4）非酒精性肝炎; 5）克罗恩病 疾病和正常人将被检查，以评估其作用和影响。 肝脏病理学对神经损伤的影响 第七组受试者也将在第一次和第二次检查之前进行检查。 一年后，肝移植。 本次调查的目的是确定a）关联 肝脏病理类型和严重程度对CNS功能的影响 B）肝移植可以逆转 明显的损害;和，c）肝功能测量的程度 可以解释各种功能障碍指数的差异。 这一信息对提高诊断水平具有重要意义 以及酗酒的医疗管理。

Six groups of subjects consisting of: 1) alcoholics without liver disease; 2) alcoholics with fatty liver (steatosis) or fibrosis; 3) alcoholics with cirrhosis with or without hepatitis; 4) nonalcoholic cirrhotics; 5) Cronh's Disease, and 6) normals will be examined to assess for the role and impact of hepatic pathology on neurologic impairment. A seventh group of subjects will also be examined prior to and again one year after, liver transplantation. The objectives of this investigation are to determine a) the association between type and severity of liver pathology on CNS functioning in alcoholics; b) the extent to which liver transplantation can reverse the manifest impairments; and, c) the extent to which hepatic function measures can account for the variance on various indices of dysfunction. This information has substantial ramifications for improving the diagnosis and medical management of alcoholism.