ALCOHOLIC LIVER PATHOLOGY: HEPATIC CEREBRAL INTERACTION

6组受试者包括：1)无肝病的酒精者； 2)酒精性脂肪肝(脂肪变性)或纤维化；3)酒精性脂肪肝 伴或不伴肝炎的肝硬变；4)非酒精性肝硬变；5)克隆氏 疾病，并对正常人进行检查，以评估其作用和影响 肝脏病理对神经损伤的影响。 第七组受试者也将在第一组之前和第二组之前接受检查 一年后，肝脏移植。 这项调查的目的是确定a)联系 肝组织病理类型与严重程度对中枢神经系统功能的影响 酗酒者；b)肝移植可以在多大程度上逆转 明显的损害；以及，c)肝功能测量的程度 可以解释各种功能障碍指数的差异。 这一信息对改善诊断有实质性的影响 以及对酒精中毒的医疗管理。

Six groups of subjects consisting of: 1) alcoholics without liver disease; 2) alcoholics with fatty liver (steatosis) or fibrosis; 3) alcoholics with cirrhosis with or without hepatitis; 4) nonalcoholic cirrhotics; 5) Cronh's Disease, and 6) normals will be examined to assess for the role and impact of hepatic pathology on neurologic impairment. A seventh group of subjects will also be examined prior to and again one year after, liver transplantation. The objectives of this investigation are to determine a) the association between type and severity of liver pathology on CNS functioning in alcoholics; b) the extent to which liver transplantation can reverse the manifest impairments; and, c) the extent to which hepatic function measures can account for the variance on various indices of dysfunction. This information has substantial ramifications for improving the diagnosis and medical management of alcoholism.