Signaling to plant immunity responses (PathoNet)

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The overall scientific goal of PathoNet is to close the gaps in our knowledge on PAMP-induced signalling such as connecting signal perception at the plasma membrane (PM) to further transduction by kinase cascades; the connection of signalling through MAPK to their targets and relating it to downstream responses; and interlink these to plant innate immunity. We offer systematic approach integrating i) identification of PAMP receptor (EFR)-interacting proteins (EIPs), ii) investigation of specific PAMP-induced MAPK signalling pathway, iii) uncovering MAPK targets by phosphoproteomics, iv) monitor whole genome activity in response to MAPK-mediated signals, v) systemic plant physiological responses, vi) plant sensitivity towards bacterial pathogens/elicitors. Thereby, our approach is covering PAMP-induced signaling starting from perception at the PM, spanning new hypothesis-led model towards identification of new pathway components, integrating data-led 'omics' and bioinformatics tools to extend current understand about plant innate immunity.