The Gli family of transcription factors in thymic epithelial cell (TEC) function and differentiation

胸腺上皮细胞 (TEC) 功能和分化中转录因子 Gli 家族

• 批准号: BB/I026324/1
• 负责人: Tessa Crompton
• 金额: $ 59.38万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FI026324%2F1
• 关键词: Gli; family; transcription; factors; thymic

T-cells are white blood cells that enable us to fight infectious disease. To do this, T cells must be able to recognize what is 'self' from what is 'non-self'. T-cells are produced in an organ called the thymus. During their maturation in the thymus, T-cells are selected so that any T-cells that might attack our-selves (attack 'self') die, but T-cells that are able to fight infections are allowed to leave. This project will study how the thymus controls which developing T-cells are allowed to complete their maturation and leave the thymus because they recognize 'non-self' and which T-cells do not complete their maturation because they recognize 'self'. We will study how three molecules called Gli1, Gli2 and Gli3 control the fate of developing T-cells and influences their ability to recognize 'self' and 'non-self'. Gli1, Gli2 and Gli3 are molecules called a transcription factors that influence which genes are active in a cell. We will find out which genes are controlled by Gli1, Gli2 and Gli3 in the thymus. We will use this information to find out how Gli1, Gli2 and Gli3 control the production of T-cells.

T细胞是白色血细胞，使我们能够对抗传染病。要做到这一点，T细胞必须能够识别什么是“自我”，什么是“非自我”。T细胞是在一个叫做胸腺的器官中产生的。在胸腺中成熟期间，T细胞被选择，以便任何可能攻击我们自己（攻击“自我”）的T细胞死亡，但能够对抗感染的T细胞被允许离开。这个项目将研究胸腺如何控制哪些发育中的T细胞被允许完成成熟并离开胸腺，因为它们识别“非自我”，哪些T细胞没有完成成熟，因为它们识别“自我”。我们将研究三种分子Gli1，Gli2和Gli3如何控制发育中的T细胞的命运，并影响它们识别“自我”和“非自我”的能力。Gli1、Gli2和Gli3是一种称为转录因子的分子，它们影响细胞中哪些基因是活跃的。我们将找出胸腺中哪些基因由Gli1、Gli2和Gli3控制。我们将利用这些信息来找出Gli1，Gli2和Gli3如何控制T细胞的产生。

项目成果

Hedgehog Signalling in the Embryonic Mouse Thymus.

• DOI: 10.3390/jdb4030022
• 发表时间: 2016-07-16
• 期刊: Journal of developmental biology
• 影响因子: 2.7
• 作者: Barbarulo A;Lau CI;Mengrelis K;Ross S;Solanki A;Saldaña JI;Crompton T
• 通讯作者: Crompton T

Transplanted human thymus slices induce and support T-cell development in mice after cryopreservation.

• DOI: 10.1002/eji.201747193
• 发表时间: 2018-04
• 期刊: European journal of immunology
• 影响因子: 5.4
• 作者: Ross S;Cheung M;Lau CI;Sebire N;Burch M;Kilbride P;Fuller B;Morris GJ;Davies EG;Crompton T
• 通讯作者: Crompton T

Tissue-derived hedgehog proteins modulate Th differentiation and disease.

• DOI: 10.4049/jimmunol.1202541
• 发表时间: 2013-03-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Furmanski AL;Saldana JI;Ono M;Sahni H;Paschalidis N;D'Acquisto F;Crompton T
• 通讯作者: Crompton T

Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation.

• DOI: 10.1016/j.jaut.2018.07.009
• 发表时间: 2018-09
• 期刊: Journal of autoimmunity
• 影响因子: 12.8
• 作者: Lau CI;Yánez DC;Solanki A;Papaioannou E;Saldaña JI;Crompton T
• 通讯作者: Crompton T

The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus.

• DOI: 10.18632/oncotarget.15241
• 发表时间: 2017-04-11
• 期刊: Oncotarget
• 作者: Lau CI;Barbarulo A;Solanki A;Saldaña JI;Crompton T
• 通讯作者: Crompton T