IN VITRO STUDIES ON CRYPTOSPORIDIUM, AN OI OF AIDS

艾滋病病原体隐孢子虫的体外研究

• 批准号: 3146745
• 负责人: Steve J Upton
• 金额: $ 13.73万
• 依托单位: KANSAS STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3146745
• 关键词: AIDS; Cryptosporidium; cell type; cryptosporidiosis; goats; growth media; microorganism growth; opportunistic infections; oxygen; tissue /cell culture

Cryptosporidium parvum (Apicomplexa) has emerged as an important opportunistic pathogen of patients suffering from the Acquired Immunodeficiency Syndrome (AIDS). Gastrointestinal involvement may become so severe in victims of AIDS that death due to diarrheal dehydration and electrolyte imbalance may occur. Our laboratory is currently examining the basic biology of surface and endogenous proteins and glycoproteins of sporozoites of C. parvum, and have developed methods of studying the parasite in vitro. Based on our preliminary observations, we believe methods can be developed whereby pharmaceutical screening and mass cultivation of C. parvum can be achieved. We propose to study the effects of atmospheric 02, host cell type, and nutritional additives in order to develop optimal conditions by which C. parvum can be studied in cultured cells.

细小隐孢子虫（顶复合体）已成为一种重要的传染病