BONE AND CARTILAGE ALLOGRAFTS IN BONE TUMOR TREATMENT

骨和软骨同种异体移植物在骨肿瘤治疗中的应用

• 批准号: 3151417
• 负责人: HENRY J MANKIN
• 金额: $ 12.88万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3151417
• 关键词: articular cartilage; autotransfusion; biological models; biopsy; bone imaging /visualization /scanning; bone neoplasms; bone transplantation; cartilage transplantation; computer graphics /printing; cryopreservation; cryoprotective agents; cyclosporines; histopathology; homologous transplantation; human therapy evaluation; immunosuppression; leukocyte antigen typing; longitudinal human study; musculoskeletal disorder diagnosis; musculoskeletal imaging /visualization /scanning; neoplasm /cancer transplantation; radionuclide diagnosis; radiotracer; technetium

Our purpose is to continue the study of the use of osteochondral allograft implantation in the management of patients with skeletal defects as a result of resection for tumor or disease or traumatic loss. Experimental studies will include: 1. Continued in depth follow-up of the patients in the clinical series with special attention to the incidence, cause and nature of complications of the procedure. 2. Continued assessment of the long term effect of massive allograft implantation on the host's immune system and the effect of such alterations on the fate of the graft. 3. Assessment of the state of the graft and causes of failure by study of the graft material obtained from those patients in whom subsequent removal of the graft is required because of infection, fracture or tumor recurrence. 4. Determination by prospective and retrospective study of the effect of adjuvant chemotherapy on the rate of incorporation of the graft and the rate of the repair process. 5. Introduction of special techniques for evaluating the graft (CT, bone scanning and NMR) and the patient's performance (gait analysis) in order to more fully define the patient's status. 6. Continued study of methods to improve banking procedures with special attention to harvesting, cryopreservation techniques, maintenance of sterility, computerized record keeping and sizing, and cost containment. 7. Further development of animal models of the osteoarticular allograft procedure and utilization of these for exploration of the effects of technical improvements in fixation, cryopreservation, alterations in histocompatibility and a variety of immunosuppressive regimens. 8. Continued experimentation on techniques of cryopreservation of cartilage segments with special attention to cryopreservative agents and conditions of freezing and thawing.

我们的目的是继续研究同种异体骨软骨移植的应用

项目成果

Advances in the management of bone tumors.

骨肿瘤治疗的进展。

• 发表时间: 1985
• 期刊: Clinical orthopaedics and related research
• 影响因子: 4.2
• 作者: Mankin,HJ;Gebhardt,MC
• 通讯作者: Gebhardt,MC

Osteoarticular and intercalary allograft transplantation in the management of malignant tumors of bone.

骨关节和嵌间同种异体移植治疗骨恶性肿瘤。

• DOI: 10.1002/1097-0142(19820815)50:4<613::aid-cncr2820500402>3.0.co;2-l
• 发表时间: 1982
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Mankin,HJ;Doppelt,SH;Sullivan,TR;Tomford,WW
• 通讯作者: Tomford,WW

Methods of banking bone and cartilage for allograft transplantation.

用于同种异体移植的骨和软骨储存方法。

• 发表时间: 1987
• 期刊: The Orthopedic clinics of North America
• 作者: Tomford,WW;Mankin,HJ;Friedlaender,GE;Doppelt,SH;Gebhardt,MC
• 通讯作者: Gebhardt,MC

Clinical experience with allograft implantation. The first ten years.

同种异体移植的临床经验。

• 发表时间: 1983
• 期刊: Clinical orthopaedics and related research
• 影响因子: 4.2
• 作者: Mankin,HJ;Doppelt,S;Tomford,W
• 通讯作者: Tomford,W

The management of chondrosarcoma of bone.

• DOI: 10.1097/00003086-198011000-00007
• 发表时间: 1980-11
• 期刊: Clinical orthopaedics and related research
• 影响因子: 4.2
• 作者: Eriksson Ai;A. Schiller;H. Mankin