BONE AND CARTILAGE ALLOGRAFTS IN BONE TUMOR TREATMENT

我们的目的是继续研究同种异体骨软骨移植的应用 骨缺损患者的治疗中的植入作为一种 因肿瘤或疾病或创伤性丧失而切除的结果。 实验研究将包括： 1.继续对临床系列中的患者进行深入随访， 特别注意并发症的发生率、原因和性质， 程序 2.大段同种异体骨移植远期疗效的持续评估 植入对宿主免疫系统的影响以及这种改变的影响 移植物的命运 3.通过以下研究评估移植物的状态和失败原因： 从那些随后被移除的患者中获得的移植材料 由于感染、骨折或肿瘤复发而需要移植物。 4.通过前瞻性和回顾性研究确定 辅助化疗对移植物和移植物结合率的影响 修复过程的速度。 5.介绍评估移植物的特殊技术（CT，骨 扫描和NMR）和患者的表现（步态分析），以便 更全面地了解患者的病情。 6.继续研究改进银行程序的方法， 注意收获，冷冻保存技术，维护 无菌性、计算机化记录保存和尺寸以及成本控制。 7.同种异体骨关节移植动物模型的进一步发展 程序和利用这些探索的影响， 在固定、冷冻保存、 组织相容性和多种免疫抑制方案。 8.软骨深低温保存技术的继续实验 特别关注冷冻保存剂和条件的部分 冻结和融化的过程。

Our purpose is to continue the study of the use of osteochondral allograft implantation in the management of patients with skeletal defects as a result of resection for tumor or disease or traumatic loss. Experimental studies will include: 1. Continued in depth follow-up of the patients in the clinical series with special attention to the incidence, cause and nature of complications of the procedure. 2. Continued assessment of the long term effect of massive allograft implantation on the host's immune system and the effect of such alterations on the fate of the graft. 3. Assessment of the state of the graft and causes of failure by study of the graft material obtained from those patients in whom subsequent removal of the graft is required because of infection, fracture or tumor recurrence. 4. Determination by prospective and retrospective study of the effect of adjuvant chemotherapy on the rate of incorporation of the graft and the rate of the repair process. 5. Introduction of special techniques for evaluating the graft (CT, bone scanning and NMR) and the patient's performance (gait analysis) in order to more fully define the patient's status. 6. Continued study of methods to improve banking procedures with special attention to harvesting, cryopreservation techniques, maintenance of sterility, computerized record keeping and sizing, and cost containment. 7. Further development of animal models of the osteoarticular allograft procedure and utilization of these for exploration of the effects of technical improvements in fixation, cryopreservation, alterations in histocompatibility and a variety of immunosuppressive regimens. 8. Continued experimentation on techniques of cryopreservation of cartilage segments with special attention to cryopreservative agents and conditions of freezing and thawing.