HYPOTHALAMIC THERMOSENSITIVITY IN GENETIC OBESITY

遗传性肥胖症中的下丘脑热敏感性

• 批准号: 3152677
• 负责人: HARRY J CARLISLE
• 金额: $ 4.67万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-12-01 至 1986-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3152677
• 关键词: bioenergetics; body temperature regulation; brown fat; hereditary hyperglycemic obesity; nutrition related tag; oxygen consumption; stereotaxic techniques

Genetically obese rodents, widely used as animal models of early-onset obesity and diabetes, have a large number of metabolic and endocrine deficiencies. This proposal deals with deficiencies in the regulation of energy balance. Obese animals tend to have a low body temperature and low metabolic rate, and they produce less heat than lean animals during a meal and during cold exposure. The energy saved in thermogenesis is stored as fat. These deficits have been attributed to faulty brown fat metabolism. The hypothesis of the present work is that central control mechanisms of temperature regulation may contribute to energy balance disequilibrium. Many observations regarding obese animals are consistent with the idea that the regulatory has been re-set to a lower level. Hypothalamic thermosensitivity will be examined by measuring oxygen consumption and dry and evaporative heat loss during hypothalamic heating and cooling at different ambient temperatures in lean and obese Zucker rats. Inferences can be drawn from these measurements regarding the thermoregulatory set point and the gain of the regulator.

遗传性肥胖啮齿类动物，广泛用作早发性 肥胖和糖尿病，有大量的代谢和内分泌 缺陷 本建议针对的是监管方面的不足之处， 能量平衡 肥胖的动物往往有一个低体温和低 它们的代谢率很高，在一顿饭中产生的热量比瘦肉型动物少。 以及在冷暴露期间。 产热过程中节省的能量储存为 胖了 这些缺陷被归因于错误的棕色脂肪代谢。 目前的工作假设是，中央控制机制， 温度调节可能导致能量平衡不平衡。 关于肥胖动物的许多观察结果与以下观点一致： 监管已被重新设置到较低的水平。 下丘脑 将通过测量耗氧量和干重来检查热敏性。 下丘脑加热和冷却过程中的蒸发热损失 在不同的环境温度下，瘦的和肥胖的Zucker大鼠。 推论 可以从这些关于体温调节设置的测量中得出 点和调节器的增益。

项目成果

A reevaluation of the role of the lateral hypothalamus in behavioral temperature regulation.

重新评估下丘脑外侧在行为温度调节中的作用。

• DOI: 10.1016/0031-9384(87)90206-x
• 发表时间: 1987
• 期刊: Physiology & behavior
• 影响因子: 2.9
• 作者: Refinetti,R;Carlisle,HJ
• 通讯作者: Carlisle,HJ

Effects of anterior and posterior hypothalamic temperature changes on thermoregulation in the rat.

下丘脑前部和后部温度变化对大鼠体温调节的影响。

• DOI: 10.1016/0031-9384(86)90486-5
• 发表时间: 1986
• 期刊: Physiology & behavior
• 影响因子: 2.9
• 作者: Refinetti,R;Carlisle,HJ
• 通讯作者: Carlisle,HJ

Complementary nature of heat production and heat intake during behavioral thermoregulation in the rat.

大鼠行为体温调节过程中产热和吸热的互补性质。

• DOI: 10.1016/s0163-1047(86)90905-2
• 发表时间: 1986
• 期刊: Behavioral and neural biology
• 作者: Refinetti,R;Carlisle,HJ
• 通讯作者: Carlisle,HJ

Cold-rearing normalizes capacity for norepinephrine-stimulated thermogenesis but not body temperature in 16-day-old fatty Zucker rats.

冷饲养可以使去甲肾上腺素刺激的产热能力正常化，但不能使 16 日龄的脂肪 Zucker 大鼠的体温正常化。

• DOI: 10.1016/0024-3205(86)90004-4
• 发表时间: 1986
• 期刊: Life sciences
• 影响因子: 6.1
• 作者: Schmidt,I;Stahl,J;Kaul,R;Carlisle,HJ
• 通讯作者: Carlisle,HJ

Maturation of thermoregulation in Zucker rats.

Zucker 大鼠体温调节的成熟。

• 发表时间: 1985
• 期刊: International journal of obesity
• 影响因子: 4.9
• 作者: Kaul,R;Schmidt,I;Carlisle,H
• 通讯作者: Carlisle,H