How does the plant UV-B photoreceptor UVR8 initiate signalling?

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Ultraviolet-B (UV-B) radiation is a minor but very energetic component of sunlight. Exposure to UV-B wavelengths (280-315 nm) has numerous effects on plants, including changes in metabolism and development. Importantly, UV-B stimulates responses in plants that protect them against the potentially damaging consequences of UV-B exposure. The effects of UV-B are due to its ability to regulate the expression of numerous plant genes, including those involved in UV-protection, biosynthesis and chloroplast function. It is therefore important to understand how UV-B is perceived by plants and how it initiates responses. A key component involved in these processes has been identified, a protein called UVR8. UVR8 acts as a photoreceptor to detect UV-B light. UVR8 physically interacts with another protein, COP1, to initiate responses to UV-B in plants. The aim of this project is to enhance understanding of how UVR8 interacts with COP1 to initiate plant responses to UV-B. Establishing the molecular mechanism of this interaction will help us to understand how UV-B regulates aspects of plant growth and development and how plants survive in sunlight.