The UVR8 UV-B-specific signalling pathway

UVR8 UV-B 特异性信号通路

• 批准号: BB/F014961/1
• 负责人: Gareth Islwyn Jenkins
• 金额: $ 55.14万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF014961%2F1
• 关键词: UVR8; UV; specific; signalling; pathway

UV-B wavelengths (280-320 nm) are an integral component of the daylight spectrum. UV-B induces physiological responses in plants, including changes in morphology and development and the regulation of various genes involved in secondary metabolism, chloroplast function and protection of the plant from damage by UV-B. Remarkably, very little is known about how UV-B is perceived by plants and how it initiates responses. However, the first component involved in these processes has recently been identified, a protein called UVR8. Moreover, UV-B exposure stimulates movement of UVR8 into the cell nucleus. The aim of this project is to define regions of the UVR8 protein involved in movement into the nucleus and the regulation of transcription and to identify proteins that interact with UVR8 to mediate these processes. An additional objective is to investigate how UVR8 associates with DNA in the region of a gene it regulates. Establishing how UVR8 is regulated and how it functions to control gene expresion will help us to understand how UV-B regulates aspects of plant growth and development and how plants survive in sunlight.

UV-B波长（280-320 nm）是日光光谱的组成部分。 UV-B诱导植物的生理反应，包括形态学和发育的变化以及涉及继发代谢的各种基因，叶绿体功能以及对植物对UV-B损害的保护。值得注意的是，关于植物如何看待UV-B及其启动反应的知识知之甚少。但是，最近已经确定了这些过程中涉及的第一个组件，一种称为UVR8的蛋白质。此外，UV-B暴露刺激UVR8​​向细胞核的运动。该项目的目的是定义参与运动中运动和转录调节的UVR8蛋白的区域，并鉴定与UVR8相互作用以介导这些过程的蛋白质。另一个目标是研究UVR8如何与它调节的基因区域中的DNA相关联。确定UVR8的调节方式以及它如何控制基因扩展的功能将有助于我们了解UV-B如何调节植物生长和发育的各个方面，以及植物如何在阳光下生存。

项目成果

Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges.

• DOI: 10.1126/science.1218091
• 发表时间: 2012-03-23
• 期刊: Science (New York, N.Y.)
• 作者: Christie JM;Arvai AS;Baxter KJ;Heilmann M;Pratt AJ;O'Hara A;Kelly SM;Hothorn M;Smith BO;Hitomi K;Jenkins GI;Getzoff ED
• 通讯作者: Getzoff ED