MICROWAVE-INDUCED HYPERTHERMIA FOR DEEP-SEATED TUMORS

微波诱导的深部肿瘤热疗

• 批准号: 3166186
• 负责人: EVAN BARR DOUPLE
• 金额: $ 9.13万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-03-01 至 1987-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3166186
• 关键词: adenocarcinoma; brain; breast neoplasms; cis platinum compound; clinical biomedical equipment; combination cancer therapy; computer simulation; histology; human tissue; ionizing radiation; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; phantom model; radiation dosage; radiation recovery; radiation sensitivity; radiobiology

This project proposes to continue the development of an interstitial microwave antenna array hyperthermia (IMAAH) system for the treatment of cancer. The system permits the implantation of from 1 to 12 antennas (outer diameter 0.8-1.6 mm) via catheters directly into the tumor, and is especially well suited for deep-seated tumors where catheters can be iserted or implanted. Further development of this system should provide the first microwave hyperthermia system able to control the power at different regions in a tumor, hence giving greater flexibility in controlling temperature distributions. The objectives of the current project include: (1) improving the effectiveness of the IMAAH system in clinical studies by improving the antenna design, by adding variable amplitude and phase to each antenna in the array, and by adding a computer based data recording and control system, thereby permitting localized control of temperatures in the tumor; (2) continuing hyperthermia toxicity studies in normal dog brain (acute and chronic studies); (3) conducting clinical studies of single transducer ultrasound (US) hyperthermia and modifying the present US system by adding an assortment of new transducers with different frequencies and diameters; (4) carefully measuring temperature distributions in human tumors and comparing the distributions produced with IMAAH and US systems; (5) studying the thermobiology of interstitial microwave hyperthermia alone, or in combination with radiation or chemotherapy in a transplantable mammary tumor (MTG-B) in the mouse, including aspects of the time-dose relationships, sequencing, thermotolerance, and potentiation by local anesthetics; and (6) investigating the effects of radiation dose rate on the interactions between IMAAH and conventional external beam irradiation on MTG-B in mice. The hyperthermia brain toxicity studies and thermobiology/radiobiology studies should lead to the design of protocols for treating brain tumors and other deep-seated cancers. The long term objective is to ascertain the efficacy of hyperthermia as an adjuvant to radiation and chemotherapy and to compare the efficacy of well-controlled localized hyperthermia against regional heating as a treatment modality in cancer.

该项目建议继续开发一种间隔性 微波天线阵热疗(IMAAH)系统治疗肺癌 癌症。该系统允许植入1至12个天线 (外径0.8-1.6毫米)通过导管直接进入肿瘤，并且是 尤其适用于深层肿瘤，在那里导管可以 异种或植入。该系统的进一步开发应能提供 第一台可控制功率的微波热疗系统 肿瘤中不同的区域，因此给予更大的灵活性 控制温度分布。当前的目标是 项目包括：(1)提高IMAAH系统在 通过增加变量改进天线设计的临床研究 向阵列中的每个天线添加幅度和相位，并通过添加一台计算机 基于数据记录和控制系统，从而允许本地化 肿瘤内温度的控制；(2)持续热疗毒性 正常狗脑的研究(急性和慢性研究)；(3)传导 单探头超声热疗的临床研究 通过添加各种新的换能器来修改当前的美国系统 具有不同的频率和直径；(4)仔细测量 人体肿瘤组织中的温度分布及其比较 用IMAAH和美国的系统生产；(5)研究 单纯组织间微波热疗或联合放射治疗 或在小鼠的可移植乳腺肿瘤(MTG-B)中进行化疗， 包括时间-剂量关系、测序、 耐热性和局部麻醉剂的增强作用；以及(6) 研究辐射剂量率对相互作用的影响 IMAAH与常规外照射对小鼠MTG-B的影响 高温脑毒性研究与热生物学/放射生物学 研究应该导致设计治疗脑瘤的方案 以及其他深层次的癌症。长期目标是确定 热疗作为放化疗辅助治疗的疗效观察 控制良好的局部热疗与单纯热疗的疗效比较 区域加热作为癌症的一种治疗方式。