MICROWAVE-INDUCED HYPERTHERMIA FOR DEEP-SEATED TUMORS

该项目建议继续开发一种间隔性 微波天线阵热疗(IMAAH)系统治疗肺癌 癌症。该系统允许植入1至12个天线 (外径0.8-1.6毫米)通过导管直接进入肿瘤，并且是 尤其适用于深层肿瘤，在那里导管可以 异种或植入。该系统的进一步开发应能提供 第一台可控制功率的微波热疗系统 肿瘤中不同的区域，因此给予更大的灵活性 控制温度分布。当前的目标是 项目包括：(1)提高IMAAH系统在 通过增加变量改进天线设计的临床研究 向阵列中的每个天线添加幅度和相位，并通过添加一台计算机 基于数据记录和控制系统，从而允许本地化 肿瘤内温度的控制；(2)持续热疗毒性 正常狗脑的研究(急性和慢性研究)；(3)传导 单探头超声热疗的临床研究 通过添加各种新的换能器来修改当前的美国系统 具有不同的频率和直径；(4)仔细测量 人体肿瘤组织中的温度分布及其比较 用IMAAH和美国的系统生产；(5)研究 单纯组织间微波热疗或联合放射治疗 或在小鼠的可移植乳腺肿瘤(MTG-B)中进行化疗， 包括时间-剂量关系、测序、 耐热性和局部麻醉剂的增强作用；以及(6) 研究辐射剂量率对相互作用的影响 IMAAH与常规外照射对小鼠MTG-B的影响 高温脑毒性研究与热生物学/放射生物学 研究应该导致设计治疗脑瘤的方案 以及其他深层次的癌症。长期目标是确定 热疗作为放化疗辅助治疗的疗效观察 控制良好的局部热疗与单纯热疗的疗效比较 区域加热作为癌症的一种治疗方式。

This project proposes to continue the development of an interstitial microwave antenna array hyperthermia (IMAAH) system for the treatment of cancer. The system permits the implantation of from 1 to 12 antennas (outer diameter 0.8-1.6 mm) via catheters directly into the tumor, and is especially well suited for deep-seated tumors where catheters can be iserted or implanted. Further development of this system should provide the first microwave hyperthermia system able to control the power at different regions in a tumor, hence giving greater flexibility in controlling temperature distributions. The objectives of the current project include: (1) improving the effectiveness of the IMAAH system in clinical studies by improving the antenna design, by adding variable amplitude and phase to each antenna in the array, and by adding a computer based data recording and control system, thereby permitting localized control of temperatures in the tumor; (2) continuing hyperthermia toxicity studies in normal dog brain (acute and chronic studies); (3) conducting clinical studies of single transducer ultrasound (US) hyperthermia and modifying the present US system by adding an assortment of new transducers with different frequencies and diameters; (4) carefully measuring temperature distributions in human tumors and comparing the distributions produced with IMAAH and US systems; (5) studying the thermobiology of interstitial microwave hyperthermia alone, or in combination with radiation or chemotherapy in a transplantable mammary tumor (MTG-B) in the mouse, including aspects of the time-dose relationships, sequencing, thermotolerance, and potentiation by local anesthetics; and (6) investigating the effects of radiation dose rate on the interactions between IMAAH and conventional external beam irradiation on MTG-B in mice. The hyperthermia brain toxicity studies and thermobiology/radiobiology studies should lead to the design of protocols for treating brain tumors and other deep-seated cancers. The long term objective is to ascertain the efficacy of hyperthermia as an adjuvant to radiation and chemotherapy and to compare the efficacy of well-controlled localized hyperthermia against regional heating as a treatment modality in cancer.