MICROWAVE-INDUCED HYPERTHERMIA FOR DEEP-SEATED TUMORS

该项目建议继续开发一种填隙式 微波天线阵列热疗（IMAAH）系统，用于治疗 癌 该系统允许植入1至12根天线 （外径0.8-1.6 mm）通过导管直接进入肿瘤， 特别适用于导管可以 隔离或植入。 该系统的进一步发展应提供 所述第一微波热疗系统能够将功率控制在 肿瘤中的不同区域，因此在 控制温度分布。 当前的目标 项目包括：（1）提高IMAAH系统的有效性， 通过改进天线设计，通过增加变量 幅度和相位到阵列中的每个天线，并通过添加计算机 基于数据记录和控制系统，从而允许本地化 控制肿瘤内温度;（2）持续高温毒性 正常犬脑的研究（急性和慢性研究）;（3）进行 单换能器超声（US）热疗的临床研究， 通过添加各种新探头来修改当前US系统 不同频率和直径;（4）仔细测量 人体肿瘤的温度分布， 生产与IMAAH和美国系统;（5）研究热生物学的 单纯组织间微波热疗或联合放射治疗 或化疗在小鼠可移植乳腺肿瘤（MTG-B）中的作用， 包括时间-剂量关系，排序， 热耐受性和局部麻醉剂的增强作用;和（6） 研究辐射剂量率对相互作用的影响 IMAAH和常规外照射对小鼠MTG-B的影响。 高温脑毒性研究与热生物学/放射生物学 这些研究应该会导致脑肿瘤治疗方案的设计 和其他深层次的癌症。 长期目标是确定 热疗作为放疗和化疗辅助治疗的有效性， 为了比较控制良好的局部热疗与 局部加热作为癌症的治疗方式。

This project proposes to continue the development of an interstitial microwave antenna array hyperthermia (IMAAH) system for the treatment of cancer. The system permits the implantation of from 1 to 12 antennas (outer diameter 0.8-1.6 mm) via catheters directly into the tumor, and is especially well suited for deep-seated tumors where catheters can be iserted or implanted. Further development of this system should provide the first microwave hyperthermia system able to control the power at different regions in a tumor, hence giving greater flexibility in controlling temperature distributions. The objectives of the current project include: (1) improving the effectiveness of the IMAAH system in clinical studies by improving the antenna design, by adding variable amplitude and phase to each antenna in the array, and by adding a computer based data recording and control system, thereby permitting localized control of temperatures in the tumor; (2) continuing hyperthermia toxicity studies in normal dog brain (acute and chronic studies); (3) conducting clinical studies of single transducer ultrasound (US) hyperthermia and modifying the present US system by adding an assortment of new transducers with different frequencies and diameters; (4) carefully measuring temperature distributions in human tumors and comparing the distributions produced with IMAAH and US systems; (5) studying the thermobiology of interstitial microwave hyperthermia alone, or in combination with radiation or chemotherapy in a transplantable mammary tumor (MTG-B) in the mouse, including aspects of the time-dose relationships, sequencing, thermotolerance, and potentiation by local anesthetics; and (6) investigating the effects of radiation dose rate on the interactions between IMAAH and conventional external beam irradiation on MTG-B in mice. The hyperthermia brain toxicity studies and thermobiology/radiobiology studies should lead to the design of protocols for treating brain tumors and other deep-seated cancers. The long term objective is to ascertain the efficacy of hyperthermia as an adjuvant to radiation and chemotherapy and to compare the efficacy of well-controlled localized hyperthermia against regional heating as a treatment modality in cancer.