MICROWAVE-INDUCED HYPERTHERMIA FOR DEEP-SEATED TUMORS

微波诱导的深部肿瘤热疗

• 批准号: 3166188
• 负责人: EVAN BARR DOUPLE
• 金额: $ 13.82万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-03-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3166188
• 关键词: adenocarcinoma; antineoplastics; biopsy; brain; breast neoplasms; cis platinum compound; clinical biomedical equipment; colony stimulating factor; combination cancer therapy; computer simulation; dogs; histology; human tissue; ionizing radiation; laboratory mouse; microwave radiation; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; neoplasm /cancer transplantation; noninvasive diagnosis; phantom model; radiation dosage; radiation recovery; radiation sensitivity; radiobiology; radiodiagnosis; swine

The long term objective of this project is to investigate the efficacy of hyperthermia as an adjuvant to radiation therapy or chemotherapy in the treatment of cancer. This proposal addresses two specific areas: (1) development and testing of improved techniques for controlling temperature distributions in superficial and deep-seated tumors, and (2) investigations of the interactions between hyperthermia and brachytherapy and between hyperthermia and certain chemotherapeutic agents. Major specific aims include the following: (1) new refinements of the interstitial microwave antenna array hyperthermia (IMAAH) system to incorporate features such as variable phase control, air cooling of antennas, and new antenna designs, together with appropriate evaluations of the refined system in animals and in clinical tumors. (2) The continued evaluation of the IMAAH system's effectiveness in heating deep-seated tumors that are difficult to heat by non-invasive systems, especially those in the abdomen and pelvic regions. (3) The use of a transplantable murine mammary tumor (MTG-B) to investigate interactions between brachytherapy and hyperthermia. These studies will evaluate the effect of parameters important to clinical protocols such as (a) sequencing, (b) time-dose relationships and (c) the influence of brachytherapy on the magnitude and kinetics of thermotolerance. In these studies tumor regrowth delay, tumor control (TCD50), and cell colony-forming units (CFU) in vitro following treatment in tumors will be used as analytical endpoints. (4) Examination of the effects of hyperthermia in combination with platinum chemotherapy in MTG-B, to be followed by pilot clinical studies of IMAAH and ultrasound induced hyperthermia in combination with platinum chemotherapy in superficial tumors so as to gain information for treating deep- seated tumors with this combined modality approach. Platinum levels will be measured in MTG-B and in the clinical tumors using atomic absorption spectrometry (AAS). Therefore, the studies proposed will not only continue to develop new techniques for providing better temperature distributions throughout the tumor and surrounding normal tissue, but will also exploit the controlled temperatures produced by these systems to obtain crucial information to further our understanding of the combination of brachytherapy or chemotherapy with hyperthermia in the treatment of cancer.

该项目的长期目标是调查 热疗作为放射治疗辅助的功效或 化疗治疗癌症。 这个提议 解决两个具体领域：（1）开发和测试 控制温度分布的改进技术 浅表和深层肿瘤，以及（2） 热疗和近距离放射治疗之间的相互作用 热疗和某些化疗药物之间的差异。 主要具体目标包括：（1）新的细化 间隙微波天线阵列热疗 (IMAAH) 系统结合了诸如可变相位控制、空气 天线的冷却和新的天线设计，以及 对动物和动物中的精制系统进行适当的评估 临床肿瘤。 （2）IMAAH的持续评估 系统在加热深部肿瘤方面的有效性 难以通过非侵入性系统加热，尤其是那些在 腹部和骨盆区域。 (3)可移植性的使用 小鼠乳腺肿瘤 (MTG-B) 研究相互作用 介于近距离放射治疗和热疗之间。 这些研究将 评估对临床方案重要的参数的影响 例如 (a) 测序、(b) 时间-剂量关系和 (c) 近距离放射治疗对强度和动力学的影响 耐热性。 在这些研究中，肿瘤再生延迟，肿瘤 对照 (TCD50) 和体外细胞集落形成单位 (CFU) 肿瘤治疗后将用作分析 端点。 (4) 热疗效果的检查 与 MTG-B 中的铂类化疗联合使用， 随后进行 IMAAH 和超声的试点临床研究 诱导热疗联合铂类化疗 浅表肿瘤，以获得治疗深部肿瘤的信息 采用这种组合方式定位肿瘤。 铂 将使用 MTG-B 和临床肿瘤来测量水平 原子吸收光谱法（AAS）。 因此，研究 提议不仅将继续开发新技术 在整个肿瘤中提供更好的温度分布 和周围的正常组织，但也会利用受控的 这些系统产生的温度以获得关键的 信息以进一步我们对组合的理解 近距离放射治疗或热疗化疗 癌症的治疗。