MICROWAVE-INDUCED HYPERTHERMIA FOR DEEP-SEATED TUMORS

这项计划的长期目标是调查 热疗辅助放射治疗的疗效观察 化疗在癌症治疗中的作用。这项建议 涉及两个具体领域：(1)开发和测试 改进的温度分布控制技术 浅层和深层肿瘤，以及(2)对 热疗与近距离放射治疗的相互作用 体温过高和某些化疗药物之间的关系。 主要具体目标包括：(一)新细化 间质微波天线阵热疗(IMAAH) 系统集成了诸如可变相位控制、空气 天线冷却，以及新的天线设计，以及 对改进系统在动物体内和体内的适当评价 临床肿瘤。(2)对IMAAH的持续评价 系统在加热深层肿瘤方面的有效性 非侵入性系统难以加热，尤其是那些 腹部和骨盆区域。(3)使用可移植的 小鼠乳腺肿瘤(MTG-B)相互作用的研究 在近距离放射治疗和热疗之间。这些研究将 评估对临床方案重要的参数的影响 例如(A)排序、(B)时间-剂量关系和(C) 近距离放射治疗对大鼠局灶性脑损伤的影响 耐热性。在这些研究中，肿瘤再生延迟，肿瘤 对照(TCD50)和体外细胞集落形成单位(CFU) 接下来的肿瘤治疗将被用作分析 终端。(4)体温升高对小鼠的影响 联合铂类化疗方案治疗MTG-B 随后进行了IMAAH和超声的初步临床研究 诱导高热联合铂类化疗 从而获得治疗深部肿瘤的信息 用这种联合方式治疗肿瘤。白金 将在MTG-B和临床肿瘤中使用 原子吸收光谱(AAS)。因此，这些研究 提议不仅将继续开发新的技术， 在整个肿瘤中提供更好的温度分布 和周围的正常组织，但也会利用受控的 这些系统产生的温度，以获得关键的 信息，以加深我们对 近距离放射治疗或热疗化疗 癌症的治疗。

The long term objective of this project is to investigate the efficacy of hyperthermia as an adjuvant to radiation therapy or chemotherapy in the treatment of cancer. This proposal addresses two specific areas: (1) development and testing of improved techniques for controlling temperature distributions in superficial and deep-seated tumors, and (2) investigations of the interactions between hyperthermia and brachytherapy and between hyperthermia and certain chemotherapeutic agents. Major specific aims include the following: (1) new refinements of the interstitial microwave antenna array hyperthermia (IMAAH) system to incorporate features such as variable phase control, air cooling of antennas, and new antenna designs, together with appropriate evaluations of the refined system in animals and in clinical tumors. (2) The continued evaluation of the IMAAH system's effectiveness in heating deep-seated tumors that are difficult to heat by non-invasive systems, especially those in the abdomen and pelvic regions. (3) The use of a transplantable murine mammary tumor (MTG-B) to investigate interactions between brachytherapy and hyperthermia. These studies will evaluate the effect of parameters important to clinical protocols such as (a) sequencing, (b) time-dose relationships and (c) the influence of brachytherapy on the magnitude and kinetics of thermotolerance. In these studies tumor regrowth delay, tumor control (TCD50), and cell colony-forming units (CFU) in vitro following treatment in tumors will be used as analytical endpoints. (4) Examination of the effects of hyperthermia in combination with platinum chemotherapy in MTG-B, to be followed by pilot clinical studies of IMAAH and ultrasound induced hyperthermia in combination with platinum chemotherapy in superficial tumors so as to gain information for treating deep- seated tumors with this combined modality approach. Platinum levels will be measured in MTG-B and in the clinical tumors using atomic absorption spectrometry (AAS). Therefore, the studies proposed will not only continue to develop new techniques for providing better temperature distributions throughout the tumor and surrounding normal tissue, but will also exploit the controlled temperatures produced by these systems to obtain crucial information to further our understanding of the combination of brachytherapy or chemotherapy with hyperthermia in the treatment of cancer.