MICROWAVE-INDUCED HYPERTHERMIA FOR DEEP-SEATED TUMORS

本项目的长期目标是调查 热疗作为放疗辅助治疗的疗效，或 化疗在癌症治疗中的应用 这项建议 涉及两个具体领域：（1）开发和测试 用于控制温度分布的改进技术 浅表和深部肿瘤，和（2）调查的 高温和近距离放射治疗之间的相互作用， 和某些化疗药物之间的联系 主要的具体目标包括：（1）对 间质微波天线阵热疗（IMAAH） 系统结合了诸如可变相位控制、空气 天线的冷却和新的天线设计，以及 在动物和动物中对精制系统进行适当的评价， 临床肿瘤 (2)对《国际医疗卫生法》的持续评估 系统在加热深层肿瘤方面的有效性， 很难通过非侵入性系统加热，特别是那些在 腹部和骨盆区域。 (3)使用可移植的 小鼠乳腺肿瘤（MTG-B）研究相互作用 近距离放射治疗和热疗之间的区别 这些研究将 评价对临床方案重要的参数的影响 例如（a）测序，（B）时间-剂量关系和（c） 近距离放射治疗对肿瘤大小和动力学的影响 耐热性 在这些研究中，肿瘤再生长延迟， 对照（TCD 50）和体外细胞集落形成单位（CFU 在肿瘤治疗后， 端点。 (4)检查高温对 与铂类化疗联合治疗MTG-B， 其次是IMAAH和超声的试点临床研究 诱导热疗联合铂类化疗 以获得治疗深部肿瘤的信息， 这种联合治疗的方法。 铂 将在MTG-B和临床肿瘤中使用 原子吸收光谱法（AAS）。 因此，研究 它不仅将继续开发新技术， 在整个肿瘤中提供更好的温度分布 和周围的正常组织，但也将利用控制 这些系统产生的温度，以获得关键的 信息，以进一步了解我们的组合 近距离放射治疗或化疗伴热疗 癌症的治疗。

The long term objective of this project is to investigate the efficacy of hyperthermia as an adjuvant to radiation therapy or chemotherapy in the treatment of cancer. This proposal addresses two specific areas: (1) development and testing of improved techniques for controlling temperature distributions in superficial and deep-seated tumors, and (2) investigations of the interactions between hyperthermia and brachytherapy and between hyperthermia and certain chemotherapeutic agents. Major specific aims include the following: (1) new refinements of the interstitial microwave antenna array hyperthermia (IMAAH) system to incorporate features such as variable phase control, air cooling of antennas, and new antenna designs, together with appropriate evaluations of the refined system in animals and in clinical tumors. (2) The continued evaluation of the IMAAH system's effectiveness in heating deep-seated tumors that are difficult to heat by non-invasive systems, especially those in the abdomen and pelvic regions. (3) The use of a transplantable murine mammary tumor (MTG-B) to investigate interactions between brachytherapy and hyperthermia. These studies will evaluate the effect of parameters important to clinical protocols such as (a) sequencing, (b) time-dose relationships and (c) the influence of brachytherapy on the magnitude and kinetics of thermotolerance. In these studies tumor regrowth delay, tumor control (TCD50), and cell colony-forming units (CFU) in vitro following treatment in tumors will be used as analytical endpoints. (4) Examination of the effects of hyperthermia in combination with platinum chemotherapy in MTG-B, to be followed by pilot clinical studies of IMAAH and ultrasound induced hyperthermia in combination with platinum chemotherapy in superficial tumors so as to gain information for treating deep- seated tumors with this combined modality approach. Platinum levels will be measured in MTG-B and in the clinical tumors using atomic absorption spectrometry (AAS). Therefore, the studies proposed will not only continue to develop new techniques for providing better temperature distributions throughout the tumor and surrounding normal tissue, but will also exploit the controlled temperatures produced by these systems to obtain crucial information to further our understanding of the combination of brachytherapy or chemotherapy with hyperthermia in the treatment of cancer.