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MICROWAVE-INDUCED HYPERTHERMIA FOR DEEP-SEATED TUMORS

微波诱导的深部肿瘤热疗

基本信息

批准号：
3166190
负责人：
EVAN BARR DOUPLE
金额：
$ 14.1万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
1980
资助国家：
美国
起止时间：
1980-03-01 至 1991-12-31
项目状态：
已结题

项目摘要

The long term objective of this project is to investigate the efficacy of hyperthermia as an adjuvant to radiation therapy or chemotherapy in the treatment of cancer. This proposal addresses two specific areas: (1) development and testing of improved techniques for controlling temperature distributions in superficial and deep-seated tumors, and (2) investigations of the interactions between hyperthermia and brachytherapy and between hyperthermia and certain chemotherapeutic agents. Major specific aims include the following: (1) new refinements of the interstitial microwave antenna array hyperthermia (IMAAH) system to incorporate features such as variable phase control, air cooling of antennas, and new antenna designs, together with appropriate evaluations of the refined system in animals and in clinical tumors. (2) The continued evaluation of the IMAAH system's effectiveness in heating deep-seated tumors that are difficult to heat by non-invasive systems, especially those in the abdomen and pelvic regions. (3) The use of a transplantable murine mammary tumor (MTG-B) to investigate interactions between brachytherapy and hyperthermia. These studies will evaluate the effect of parameters important to clinical protocols such as (a) sequencing, (b) time-dose relationships and (c) the influence of brachytherapy on the magnitude and kinetics of thermotolerance. In these studies tumor regrowth delay, tumor control (TCD50), and cell colony-forming units (CFU) in vitro following treatment in tumors will be used as analytical endpoints. (4) Examination of the effects of hyperthermia in combination with platinum chemotherapy in MTG-B, to be followed by pilot clinical studies of IMAAH and ultrasound induced hyperthermia in combination with platinum chemotherapy in superficial tumors so as to gain information for treating deep- seated tumors with this combined modality approach. Platinum levels will be measured in MTG-B and in the clinical tumors using atomic absorption spectrometry (AAS). Therefore, the studies proposed will not only continue to develop new techniques for providing better temperature distributions throughout the tumor and surrounding normal tissue, but will also exploit the controlled temperatures produced by these systems to obtain crucial information to further our understanding of the combination of brachytherapy or chemotherapy with hyperthermia in the treatment of cancer.

本项目的长期目标是调查热疗作为放疗辅助治疗的疗效，或化疗在癌症治疗中的应用这项建议涉及两个具体领域：（1）开发和测试用于控制温度分布的改进技术浅表和深部肿瘤，和（2）调查的热疗和近距离放射治疗之间的相互作用，和某些化疗药物之间的联系主要的具体目标包括：（1）对间质微波天线阵热疗（IMAAH）系统结合了诸如可变相位控制、空气天线的冷却和新的天线设计，以及在动物和动物中对精制系统进行适当的评价，临床肿瘤。 (2)对《国际医疗卫生法》的持续评估系统在加热深层肿瘤方面的有效性，很难通过非侵入性系统加热，特别是那些在腹部和骨盆区域。 (3)使用可移植的小鼠乳腺肿瘤（MTG-B）研究相互作用近距离放射治疗和热疗之间的区别这些研究将评价对临床方案重要的参数的影响例如（a）测序，（B）时间-剂量关系和（c）近距离放射治疗对肿瘤大小和动力学的影响耐热性在这些研究中，肿瘤再生长延迟，对照（TCD 50）和体外细胞集落形成单位（CFU 在肿瘤治疗后，端点。 (4)检查高温对与铂类化疗联合治疗MTG-B，其次是IMAAH和超声的试点临床研究诱导热疗联合铂类化疗以获得治疗深部肿瘤的信息，这种联合治疗的方法。铂将在MTG-B和临床肿瘤中使用原子吸收光谱法（AAS）。因此，研究它不仅将继续开发新技术，在整个肿瘤中提供更好的温度分布和周围的正常组织，但也将利用控制这些系统产生的温度，以获得关键的信息，以进一步了解我们的组合近距离放射治疗或化疗伴热疗癌症的治疗。