RADIATION REPAIR OF NORMAL MAMMALIAN TISSUES

本研究的目的是定量评估患者的反应 微血管系统和其他犬类正常组织单独辐射，并在 与其他药物联合使用。特别令人感兴趣的是确定 高线性能量转移(LET)的相对生物效应(RBE) 辐射，以及亚致死率修复能力的潜在丧失 高LET辐射或低LET辐射组合造成的辐射损伤 和其他特工在一起。多组分辐照将允许测量 每部分的修复量。多个馏分的RBE计算将 基于根据剂量反应确定的引起等效应所需的剂量 用相同数量的不同剂量的辐射获得的曲线 60Co伽马辐射和介子或中子辐射的组份。 在这项工作中将强调微血管研究；然而， 将评估心脏对辐射的影响，随着技术的发展，大脑 和脊髓将被包括在内。微血管系统的反应将是 60Co伽马辐射单次剂量和多次剂量组合的测定 加热后，辐射防护剂WR-2721和癌症化疗药物 利息。心脏对各种辐射方法的反应将是 通过对血清蛋白、血清同工酶、 放射摄影术、超声心动图和心电图术。形态计量分析 将会做心肌切除手术。在整个研究过程中，将努力 将测试值的早期变化与观察到的辐射效应相关联 后来。其中一些测试可能是晚期并发症的早期指标。

This research is intended to evaluate quantitatively the response of microvasculature and other canine normal tissues to radiation alone, and in combination with other agents. Of specific interest are the determination of the relative biological effectiveness (RBE) of high linear energy transfer (LET) radiations, and the potential loss of capability for repair of sublethal radiation damage from high LET radiations or low LET radiations in combination with other agents. Multifraction irradiation will permit measurement of the amount of repair per fraction. Calculations of RBE for multiple fractions will be based on doses required to cause an isoeffect determined from dose response curves obtained by irradiation to variable doses given in an equal number of fractions for 60Co gamma radiation and pion or neutron irradiation. Microvascular studies will be emphasized in this work; however, response of the heart to irradiation will be evaluated, and as techniques are developed, brain and spinal cord will be included. The response of the microvasculature will be determined for single and multifraction doses of 60Co gamma radiation combined with heat, the radioprotector WR-2721 and cancer chemotherapeutic agents of interest. The response of the heart to various methods of irradiation will be compared by sequential evaluations of serum protein, serum isoenzymes, radiography, echocardiography, and electrocardiography. Morphometric analysis of the myocardium will be done. Throughout this research, efforts will be made to correlate early alterations in test values with radiation effects observed later. Some of the tests may be early indicators of late complications.