ANIHWA call 1: MADISUP. Marek's Disease Virus induced immunosuppression: From diagnosis to vaccination

马立克氏病病毒（MDV）是一种高度致瘤的α疱疹病毒，在家禽生产中造成很高的经济损失。除了急性死亡或广泛的肿瘤形成，MDV诱导免疫抑制（IS），从而增加鸡对其他病原体的易感性。除了是动物健康和福利的问题之外，它还增加了对药物治疗的需求以及对针对多种病原体的疫苗接种频率的需求，因为MDV感染显示出强烈降低疫苗应答。此外，MDV疫苗本身诱导轻度IS，因此导致MDV疫苗接种的绝对必要性和对其他疫苗的反应降低之间的两难境地。尽管IS现象已被认识了几十年，但迄今为止对MDV诱导IS背后的机制知之甚少。我们的目标是应用独特的专业知识和技术，在过去几年中开发的联盟对MDV和鸡免疫学，以确定与IS相关的基本机制，并开发新的MDV疫苗显着降低免疫抑制性能。

Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes high economic losses in poultry production. Beside acute death or extensive tumor formation, MDV induces immunosuppression (IS) thus increasing the susceptibility of chickens to other pathogens. Besides being an issue of animal health and welfare, it increases the need for pharmacological treatment and also for the frequency of vaccination against multitude of pathogens, as MDV infection was shown to strongly reduce vaccine responses. Furthermore, MDV vaccines themselves induce mild IS, as such causing a dilemma between the absolute necessity of a MDV vaccination and the reduced response to other vaccines.Though the phenomenon of IS has been recognised for decades, very little is known about the mechanisms behind MDV-induced IS to date. Our goal is to apply the unique expertise and the techniques developed over the last years by the consortium on MDV and chicken immunology to identify the basic mechanisms associated with IS, and to develop novel MDV vaccines with significantly reduced immunosuppressive properties.