EPIDEMIOLOGY, IMM, VIROLOGY IN HOMOSEXUALS WITH PGL

PGL 同性恋流行病学、IMM、病毒学

• 批准号: 3173844
• 负责人: ALEXANDRA M LEVINE
• 金额: $ 30.44万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-15 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3173844
• 关键词: AIDS; B lymphocyte; Betaherpesvirinae; DNA; Epstein Barr virus; T lymphocyte; Toxoplasma; biopsy; blood chemistry; cancer risk; case history; cellular oncology; electrophoresis; gene expression; hepatitis B virus group; homosexuals; human T cell lymphotropic virus type 1; human subject; interleukin 2; karyotype; lymphoma; macrophage; microorganism immunology; molecular oncology; neoplasm /cancer immunodiagnosis; neoplasm /cancer immunology; oncogenes; questionnaires; serology /serodiagnosis; virus antigen; virus cytopathogenic effect

This document describes a proposal to investigate: (1) the development of malignant lymphoma in homosexual men with persistent, generalized lymphadenopathy (PGL) and AIDS-like immune dysfunction (acquired immunodeficiency syndrome); (2) factors responsible for the development of this state; and (3) the development of PGL or AIDS or malignant lymphoma in sexual contacts of these patients. Patients will be examined at 6 month intervals, and have serial lymph node biopsies and blood specimens taken. The lymph nodes will be investigated for morphologic expression, and for quantitative and qualitative changes in lymphocyte populations. In addition, DNA content analysis, oncogene expression, chromosomal karyotypes, and staining for various viral antigens (EB, CMV, HTLV) will be performed on the nodes. Serial evaluation of immunologic function will be performed at 6 monthly intervals, including B and T lymphocyte numbers and subsets, Interleukin I and II levels, natural killer and macrophage cytotoxicity. Serologic evidence of infection to a variety of agents (CMV, EB, HTLV, Hepatitis B, toxoplasmosis) will be studied. In addition, a careful epidemiologic evaluation will be performed. All of these parameters will be evaluated serially, in order to note changes which may be associated with the development of lymphoma. Patients will be compared to friend controls who are sexual contacts and with other homosexual controls by means of serial evaluation at six month intervals, with epidemiologic questionnaire, viral serologic and immunologic studies, identical to those performed on the patients, in order to discover those factors responsible for the development of the lymphadenopathy syndrome, or for lymphoma, or for AIDS in the normal homosexual population.

本文件描述了一项调查建议：（1）开发 男性同性恋者恶性淋巴瘤伴持续性全身性 淋巴结病（PGL）和艾滋病样免疫功能障碍（获得性 免疫缺陷综合征）;（2）负责发展的因素 这种状态;和（3）PGL或艾滋病或恶性淋巴瘤的发展， 这些患者的性接触。 患者将每6个月检查一次，并有连续淋巴结转移。 活检和采集血液样本。 将对淋巴结进行检查 形态学表达，以及定量和定性变化， 淋巴细胞群 此外，DNA含量分析、癌基因 表达、染色体核型和各种病毒抗原的染色 (EB、CMV、HTLV）。 系列评价 每6个月进行一次免疫功能检查，包括B T淋巴细胞数量和亚群，白细胞介素I和II水平，自然 杀伤细胞和巨噬细胞细胞毒性。 感染的血清学证据 将使用多种病原体（CMV、EB、HTLV、B型肝炎、弓形虫病） 研究了 此外，还将进行仔细的流行病学评估， 执行。 所有这些参数将连续评估，以便 注意可能与淋巴瘤发展相关的变化。 将患者与性接触的朋友对照进行比较， 与其他同性恋对照组在6个月时进行系列评价 间隔，流行病学调查问卷，病毒血清学和 免疫学研究，与对患者进行的研究相同， 去发现那些导致 淋巴结病综合征，或淋巴瘤，或艾滋病在正常 同性恋人口

项目成果

Immunophenotypic analysis of peripheral blood leukocytes at different stages of HIV infection. An analysis of asymptomatic, ARC, and AIDS populations.

HIV感染不同阶段外周血白细胞的免疫表型分析。

• DOI: 10.1093/ajcp/92.3.300
• 发表时间: 1989
• 期刊: American journal of clinical pathology
• 影响因子: 3.5
• 作者: Formenti,SC;Turner,RR;deMartini,RM;Boone,DC;Bishop,PC;Levine,AM;Parker,JW
• 通讯作者: Parker,JW

Flow cytometric lymphocyte immunophenotyping in homosexual men with the persistent generalized lymphadenopathy syndrome: a longitudinal study of lymph nodes and blood.

患有持续性全身性淋巴结病综合征的同性恋男性的流式细胞术淋巴细胞免疫表型：淋巴结和血液的纵向研究。

• 发表时间: 1987
• 期刊: Diagnostic and clinical immunology
• 作者: Turner,RR;Boone,DC;Levine,AM;Nichols,PW;Parker,JW
• 通讯作者: Parker,JW

Retrovirus and malignant lymphoma in homosexual men.

男性同性恋者的逆转录病毒和恶性淋巴瘤。

• 发表时间: 1985
• 期刊: JAMA : the journal of the American Medical Association
• 作者: Levine,AM;Gill,PS;Meyer,PR;Burkes,RL;Ross,R;Dworsky,RD;Krailo,M;Parker,JW;Lukes,RJ;Rasheed,S
• 通讯作者: Rasheed,S

Progressive histopathologic abnormalities in the persistent generalized lymphadenopathy syndrome.

持续性全身淋巴结病综合征的进行性组织病理学异常。

• DOI: 10.1097/00000478-198708000-00006
• 发表时间: 1987
• 期刊: The American journal of surgical pathology
• 作者: Turner,RR;Levine,AM;Gill,PS;Parker,JW;Meyer,PR
• 通讯作者: Meyer,PR

B-cell lymphoma in two monogamous homosexual men.

两名一夫一妻制同性恋男性的 B 细胞淋巴瘤。

• 发表时间: 1985
• 期刊: Archives of internal medicine
• 作者: Levine,AM;Burkes,RL;Walker,M;Meyer,PR;Gill,PS;Nichols,PW;Dworsky,R;Parker,JW;Lukes,RJ
• 通讯作者: Lukes,RJ