霍奇金相关抗体的分离-猫眼课题宝

霍奇金相关抗体的分离

批准号：

3174036

负责人：

CLIVE R TAYLOR

金额：

$12.72万

依托单位：

UNIVERSITY OF SOUTHERN CALIFORNIA

依托单位国家：

美国

项目类别：

财政年份：

1984

资助国家：

美国

项目状态：

已结题

起止时间：

1984-07-01 至 1987-06-30

来源：

https://reporter.nih.gov/project-details/3174036

关键词：

Hodgkin's disease autoantibody enzyme linked immunosorbent assay histology human subject hybridomas immune complex immunochemistry immunological substance immunoperoxidase leukocyte activation /transformation monoclonal antibody neoplasm /cancer immunodiagnosis serology /serodiagnosis surface antigens

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英文摘要

We have obtained four human antibodies that show reactivity with a variety of human cell types in tissue sections, including Reed Sternberg cells. We have commenced production of these antibodies in sufficient amounts, free of mouse immunoglobulin, for direct biotinylation studies; and preparation of F(ab)2 reagents. We have also obtained a panel of T&B cell lines and Poppema's Reed Sternberg cell lines, and have commenced characterization of those antibodies with those cell lines with a vein to antigen isolation. (2)

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