CAFFEINE & EXPERIMENTAL MAMMARY GLAND TUMORIGENESIS

咖啡因

• 批准号: 3175393
• 负责人: CLIFFORD W WELSCH
• 金额: $ 10.23万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3175393
• 关键词: benzanthracenes; blood chemistry; breast neoplasms; caffeine; cancer risk; chemical carcinogen; chemical carcinogenesis; disease /disorder model; dosage; drug administration routes; estradiol; estrogens; follicle stimulating hormone; growth /development; histopathology; hormone related neoplasm /cancer; laboratory mouse; laboratory rat; luteinizing hormone; mammary gland; nitrosourea; pediatric pharmacology; pregnancy; progesterone; prolactin; tumor promoters

Caffeine (1,3,7-trimethylxanthine) holds the dubious distinction of being the most widely used psychotropic drug in North America. The methylated purine is most often consumed in colas, teas, chocolates and numerous prescription and non-prescription drugs. Despite the ubiquitous consumption of the drug, we still do not know whether or not the drug is an important contributing "lifestyle" factor in the genesis of malignant disease. Such is the case with human breast tumors (benign and malignant); controversy still exists as to whether or not caffeine consumption contributes to human breast tumorigenesis. During the past 3 years, our studies provide evidence that caffeine consumption (via the drinking water) can indeed effect (inhibit and enhance) mammary gland tumorigenesis in experimental animals, a phenomenon that is dependent upon the time-span of caffeine treatment, the dose of caffeine used and the animal model examined. In this research proposal, we intend to further examine the role of caffeine in experimental animal (rat and mouse) mammary gland tumorigenesis. Specifically, we intend to: 1) further evaluate the role of caffeine in DMBA-induced rat mammary gland tumorigenesis and, in addition, examine the role of caffeine in the MNU-induced rat mammary carcinoma model and in the pregnancy- and hormone-induced mouse mammary carcinoma model. In addition, we intend to: 2) examine the influence of caffeine on normal mammary gland developmental growth processes in immature and mature mice and 3) determine the influence of caffeine on mammotropic hormone secretion in immature and mature rats. These studies are designed to extend our current understanding of the influence of caffeine on normal and neoplastic mammary gland developmental growth processes and provide insight into the mechanism by which the drug influences these processes.

咖啡因（1,3,7-三甲基黄嘌呤）具有可疑的区别

项目成果

Influence of caffeine consumption on 7,12-dimethylbenz(a)anthracene-induced mammary gland tumorigenesis in female rats fed a chemically defined diet containing standard and high levels of unsaturated fat.

摄入含有标准和高水平不饱和脂肪的化学限定饮食的雌性大鼠中，咖啡因摄入量对 7,12-二甲基苯并（a）蒽诱导的乳腺肿瘤发生的影响。

• 发表时间: 1988
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Welsch,CW;DeHoog,JV
• 通讯作者: DeHoog,JV

Caffeine and the development of normal, benign and carcinomatous human breast tissues: a relationship?

咖啡因与正常、良性和癌性人类乳腺组织的发育：有关系吗？

• 发表时间: 1990
• 期刊: Journal of medicine
• 作者: Wolfrom,D;Welsch,CW
• 通讯作者: Welsch,CW

Caffeine, theophylline, theobromine, and developmental growth of the mouse mammary gland.

咖啡因、茶碱、可可碱和小鼠乳腺的发育生长。

• 发表时间: 1992
• 期刊: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
• 作者: VanderPloeg,LC;Wolfrom,DM;Rao,AR;Braselton,WE;Welsch,CW
• 通讯作者: Welsch,CW

Influence of caffeine on development of benign and carcinomatous mammary gland tumors in female rats treated with the carcinogens 7,12-dimethylbenz(a)anthracene and N-methyl-N-nitrosourea.

咖啡因对接受致癌物 7,12-二甲基苯并（a）蒽和 N-甲基-N-亚硝基脲治疗的雌性大鼠良性和癌性乳腺肿瘤发展的影响。

• 发表时间: 1991
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: VanderPloeg,LC;Wolfrom,DM;Welsch,CW
• 通讯作者: Welsch,CW

Caffeine inhibits development of benign mammary gland tumors in carcinogen-treated female Sprague-Dawley rats.

咖啡因抑制经致癌物治疗的雌性斯普拉格-道利大鼠良性乳腺肿瘤的发展。

• DOI: 10.1007/bf01961163
• 发表时间: 1991
• 期刊: Breast cancer research and treatment
• 影响因子: 3.8
• 作者: Wolfrom,DM;Rao,AR;Welsch,CW
• 通讯作者: Welsch,CW