UK-US Collaboration on Structure, Function and Dynamics of Voltage-Gated Sodium Channels

英美合作研究电压门控钠通道的结构、功能和动力学

• 批准号: BB/L026252/1
• 负责人: Bonnie Wallace
• 金额: $ 5.46万
• 依托单位: Birkbeck, University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL026252%2F1
• 关键词: UK; US; Collaboration; Structure; Function

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

GTR目前尚未用于所有资助研究的摘要。这通常是因为提交提案时不需要摘要，但可能是因为它包含了敏感信息，例如个人详细信息。

项目成果

Molecular Dynamics Simulations of the Open State Structure of a Bacterial Voltage-Gated Sodium Channel Reveal the Binding Mechanisms of Channel Blockers

细菌电压门控钠通道开放态结构的分子动力学模拟揭示了通道阻断剂的结合机制

• 发表时间: 2016
• 期刊: BIOPHYSICAL JOURNAL
• 影响因子: 3.4
• 作者: Ke Song

Tamoxifen complexes with the voltage-gated sodium channel reveal novel drug binding sites

他莫昔芬与电压门控钠通道的复合物揭示了新的药物结合位点

• DOI: 10.1016/j.bpj.2021.11.2583
• 发表时间: 2022
• 期刊: Biophysical Journal
• 影响因子: 3.4
• 作者: Hollingworth D

The T1-tetramerisation domain of Kv1.2 rescues expression and preserves function of a truncated NaChBac sodium channel.

• DOI: 10.1002/1873-3468.14279
• 发表时间: 2022-03
• 期刊: FEBS LETTERS
• 影响因子: 3.5
• 作者: D'Avanzo, Nazzareno;Miles, Andrew J.;Powl, Andrew M.;Nichols, Colin G.;Wallace, B. A.;O'Reilly, Andrias O.
• 通讯作者: O'Reilly, Andrias O.

Structural model of the open-closed-inactivated cycle of prokaryotic voltage-gated sodium channels.

• DOI: 10.1085/jgp.201411242
• 发表时间: 2015-01
• 期刊: The Journal of general physiology
• 作者: Bagnéris C;Naylor CE;McCusker EC;Wallace BA
• 通讯作者: Wallace BA

Molecular basis of ion permeability in a voltage-gated sodium channel.

• DOI: 10.15252/embj.201593285
• 发表时间: 2016-04-15
• 期刊: The EMBO journal
• 作者: Naylor CE;Bagnéris C;DeCaen PG;Sula A;Scaglione A;Clapham DE;Wallace BA
• 通讯作者: Wallace BA