Gramicidin/Lipid Co-Crystals
Gramicidin/Lipid Co-Crystals
批准号:
8816981
负责人:
Bonnie Wallace
金额:
$31.5万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-03-01 至 1994-02-28
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Dr. Wallace is determining the structure of the gramicidin A transmembrane ion channel using X-ray crystallography and co- crystals of gramicidin and phospholipids. The crystals currently available for study diffract to better than 2.0 A resolution. Spectroscopic studies on these crystals have shown that the lipid molecules are highly ordered within the co-crystals. The plasma membrane is responsible for the interactions of a cell with its environment and neighboring cells. Membrane proteins play a major role in transport processes, cell-cell contact and signal reception. High resolution information concerning the structure of proteins which are embedded in lipid bilayers may elucidate their functional roles as channels and receptors and provide insight into the folding of proteins in the hydrophobic environment of a lipid bilayer.***//
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Structure/Function Drug Interaction Studies on Voltage-Gated Sodium Channels
-
批准号:BB/V018035/1
-
项目类别:Research Grant
-
资助金额:$3.9万
-
财政年份:2022
-
负责人:Bonnie Wallace
-
依托单位:
Binding and interactions of Brazilian toxins to voltage-gated sodium channels: The Rational Search for New Drugs
-
批准号:BB/T01153X/1
-
项目类别:Research Grant
-
资助金额:$2.03万
-
财政年份:2020
-
负责人:Bonnie Wallace
-
依托单位:
Bioinformatics Resources for Circular Dichroism Spectroscopy and Structural Biology: Operation, Enhancement, Curation, and New Developments
-
批准号:BB/P024092/1
-
项目类别:Research Grant
-
资助金额:$93.79万
-
财政年份:2018
-
负责人:Bonnie Wallace
-
依托单位:
Structure and Function of the Human 1.8 Voltage-Gated Sodium Channel Associated with Pain Sensation
-
批准号:BB/R001294/1
-
项目类别:Research Grant
-
资助金额:$73.99万
-
财政年份:2017
-
负责人:Bonnie Wallace
-
依托单位:
Biophysical studies of the structure/function of antimicrobial peptides and enzymes isolated from extremophile organisms
-
批准号:BB/N012763/1
-
项目类别:Research Grant
-
资助金额:$4.51万
-
财政年份:2016
-
负责人:Bonnie Wallace
-
依托单位:
UK-US Collaboration on Structure, Function and Dynamics of Voltage-Gated Sodium Channels
-
批准号:BB/L026252/1
-
项目类别:Research Grant
-
资助金额:$5.46万
-
财政年份:2014
-
负责人:Bonnie Wallace
-
依托单位:
Structure and Function of Voltage-Gated Ion Channels and their Applications for Rational Drug Design
-
批准号:BB/L006790/1
-
项目类别:Research Grant
-
资助金额:$67.84万
-
财政年份:2014
-
负责人:Bonnie Wallace
-
依托单位:
The Protein Circular Dichroism Data Bank, the DichroWeb Server, and ValiDichro: Data Sharing, Analysis and Standards Resources for CD Spectroscopy
-
批准号:BB/J019135/1
-
项目类别:Research Grant
-
资助金额:$87.31万
-
财政年份:2013
-
负责人:Bonnie Wallace
-
依托单位:
UK/Taiwan Interchange on Synchrotron Radiation Circular Dichroism Spectroscopy
-
批准号:BB/L004976/1
-
项目类别:Research Grant
-
资助金额:$1.58万
-
财政年份:2013
-
负责人:Bonnie Wallace
-
依托单位:
Powder Diffraction Methods for Membrane Protein Structure Determination
-
批准号:BB/J020702/1
-
项目类别:Research Grant
-
资助金额:$14.95万
-
财政年份:2012
-
负责人:Bonnie Wallace
-
依托单位:
An International UK-Brazil Collaboration using Synchrotron Radiation Circular Dichroism Spectroscopy to Study Protein Structure and Function
-
批准号:BB/J019747/1
-
项目类别:Research Grant
-
资助金额:$3.49万
-
财政年份:2012
-
负责人:Bonnie Wallace
-
依托单位:
Developing Oriented Circular Dichroism Spectroscopy as a Methodological Tool for Characterising Membrane Proteins
-
批准号:BB/H023852/1
-
项目类别:Research Grant
-
资助金额:$15.4万
-
财政年份:2011
-
负责人:Bonnie Wallace
-
依托单位:
Crystal structure analysis of a voltage-gated sodium channel
-
批准号:BB/H01070X/1
-
项目类别:Research Grant
-
资助金额:$65.4万
-
财政年份:2010
-
负责人:Bonnie Wallace
-
依托单位:
Parallel electrophysiological characterization of sodium channels
-
批准号:EP/H043888/1
-
项目类别:Research Grant
-
资助金额:$60.97万
-
财政年份:2010
-
负责人:Bonnie Wallace
-
依托单位:
VALDICHRO a software tool for validation of circular dichroism spectroscopic data and bioprocess quality analyses
-
批准号:BB/G023476/1
-
项目类别:Research Grant
-
资助金额:$14.85万
-
财政年份:2009
-
负责人:Bonnie Wallace
-
依托单位:
Developing Synchrotron Radiation Circular Dichroism (SRCD) Spectroscopy Methods and Applications for Structural Biology
-
批准号:BB/G530417/1
-
项目类别:Research Grant
-
资助金额:$5.71万
-
财政年份:2009
-
负责人:Bonnie Wallace
-
依托单位:
Support for the Protein Circular Dichroism Data Bank and the Dichroweb Analysis Server
-
批准号:BB/F010346/1
-
项目类别:Research Grant
-
资助金额:$54.86万
-
财政年份:2008
-
负责人:Bonnie Wallace
-
依托单位:
Analyses of aphid sodium channels and prediction of pesticide interactions
-
批准号:BB/F009143/1
-
项目类别:Research Grant
-
资助金额:$12.83万
-
财政年份:2008
-
负责人:Bonnie Wallace
-
依托单位:
Fold recognition by synchrotron radiation circular dichroism spectroscopy: a new tool for structural proteomics and structural molecular biology
-
批准号:BB/D008581/1
-
项目类别:Research Grant
-
资助金额:$34.47万
-
财政年份:2006
-
负责人:Bonnie Wallace
-
依托单位:
The Structure of Gramicidin, a Transmembrane Channel
-
批准号:8517866
-
项目类别:Standard Grant
-
资助金额:$0.23万
-
财政年份:1986
-
负责人:Bonnie Wallace
-
依托单位:
国内基金
海外基金
登录
查看更多内容
新肿瘤靶标 DHCR24/Lipid-Rafts 轴在急性髓系白血病中的作用和分子机制研究
-
批准号:LQ22H080007
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2021
-
负责人:吴照星
-
依托单位:
4-胺基阿拉伯糖基修饰的活性寡糖分子lipid A及衍生物的合成研究
-
批准号:22007080
-
项目类别:青年科学基金项目
-
资助金额:24.0万元
-
批准年份:2020
-
负责人:朱玉根
-
依托单位:
CRISPR/Cas9基因编辑 PLGA/Lipid纳米可视递送系统靶向治疗骨关节炎的作用机制研究
-
批准号:2020A151501615
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2020
-
负责人:于博
-
依托单位:
CRISPR/Cas9基因编辑PLGA/Lipid纳米可视递送系统靶向治疗骨关节炎的作用机制研究
-
批准号:81974323
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2019
-
负责人:于博
-
依托单位:
超声示踪载药PLGA/Lipid复合纳泡修饰的BMSCs及其调控修复骨质疏松性骨损伤的研究
-
批准号:81871355
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2018
-
负责人:陈彦
-
依托单位:
可穿透胰腺癌双重屏障的肿瘤微环境响应型多级HSA/lipid纳米递药系统研究
-
批准号:81703010
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2017
-
负责人:魏彦
-
依托单位:
革兰阴性菌中合成Kdo2-Lipid A的蛋白质反应机理研究及抑制剂筛选
-
批准号:31370731
-
项目类别:面上项目
-
资助金额:82.0万元
-
批准年份:2013
-
负责人:姚闵
-
依托单位:
以lipid A 为靶点的黄连解毒汤抗内毒素的物质基础及作用机制研究
-
批准号:81303205
-
项目类别:青年科学基金项目
-
资助金额:23.0万元
-
批准年份:2013
-
负责人:陈桂荣
-
依托单位:
lipid raft/caveolae调节PMVECs接触性抑制在肝肺综合症肺微血管扩张中的作用和机制研究
-
批准号:81270510
-
项目类别:面上项目
-
资助金额:65.0万元
-
批准年份:2012
-
负责人:鲁开智
-
依托单位:
Lipid rafts调控干燥综合征唾液腺上皮细胞凋亡信号的分子机制
-
批准号:30671948
-
项目类别:面上项目
-
资助金额:27.0万元
-
批准年份:2006
-
负责人:李萍
-
依托单位: