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Bioinformatics Resources for Circular Dichroism Spectroscopy and Structural Biology: Operation, Enhancement, Curation, and New Developments

圆二色光谱和结构生物学的生物信息学资源：操作、增强、管理和新发展

基本信息

批准号：
BB/P024092/1
负责人：
Bonnie Wallace
金额：
$ 93.79万
依托单位：
Birkbeck, University of London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FP024092%2F1
关键词：
Bioinformatics Resources Circular Dichroism Spectroscopy

项目摘要

This proposal is for a renewal of the previously-funded Bioinformatics and Biological Resources Fund project "The Protein Circular Dichroism Data Bank, the DichroWeb Server, and ValiDichro: Data Sharing, Analysis and Standards Resources for CD Spectroscopy", which enabled the creation, curation, operation and development of the unique Protein Circular Dichroism Data Bank (PCDDB) for free public data-sharing of spectroscopic and meta-data, DichroWeb, the most widely-used resource (in the UK and internationally) for analysis of CD spectra, and the advancement of data quality standards and validation protocols. This project's aims are to operate, curate, enhance, and maintain these comprehensive electronic archiving and analysis resources for CD spectroscopy which are widely used by both the academic and commercial (bigPharma, SMEs, food industry) sectors in the life sciences. It also aims to develop new analysis tools for structural biology, and to promote data-sharing, including the reuse and re-purposing of archived data. This will maximise public benefit from data generated by UK research council-funded studies. The project would also support the development of a new suite of tools for novel types of analyses (including cross-methodological ones), and a "one-stop-shop" server providing a pipeline for processing, analysis, display, and data bank deposition (thereby simplifying and improving the use of CD spectroscopy by the non-expert community, and the speeding up of these processes for regular CD users). An added value for the resources is that they are used in teaching undergraduate and graduate students, and through workshops, videos, publications, and user training sessions, we will provide educational as well as operational tools. These projects have strong support from both the UK and international user communities, as indicated by the letters of support included with the proposal. In summary, these bioinformatics and data-sharing resources provide a comprehensive package of enabling and supportive tools in CD spectroscopy for academic and industrial biochemists, structural biologist, and bioinformaticists.

这项提案是为了更新以前资助的生物信息学和生物资源基金项目“蛋白质圆二色谱数据库、DichroWeb服务器和ValiDichro：CD光谱数据共享、分析和标准资源”，该项目使唯一的蛋白质圆二色谱数据库(PCDDB)得以建立、管理、运作和开发，以实现光谱和元数据的免费公共数据共享，DichroWeb是(在英国和国际上)用于CD光谱分析的最广泛使用的资源，并改进了数据质量标准和验证协议。该项目的目的是操作、管理、增强和维护这些广泛用于CD光谱的电子存档和分析资源，这些资源在生命科学的学术和商业部门(大制药、中小企业、食品工业)中都被广泛使用。它还旨在为结构生物学开发新的分析工具，并促进数据共享，包括对存档数据的再利用和再利用。这将使公众最大限度地受益于英国研究委员会资助的研究产生的数据。该项目还将支持开发一套用于新型分析(包括跨方法分析)的新工具，以及提供处理、分析、显示和数据库存储管道的“一站式”服务器(从而简化和改进非专家群体对光谱学的使用，并为常规光谱分析用户加快这些过程)。这些资源的一个附加价值是，它们用于本科生和研究生的教学，并通过研讨会、视频、出版物和用户培训课程，我们将提供教育和操作工具。提案中的支持函表明，这些项目得到了英国和国际用户群体的大力支持。总之，这些生物信息学和数据共享资源为学术和工业生物化学家、结构生物学家和生物信息学家提供了一套全面的CD光谱学支持和支持工具。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The T1-tetramerisation domain of Kv1.2 rescues expression and preserves function of a truncated NaChBac sodium channel.

DOI：
10.1002/1873-3468.14279
发表时间：
2022-03
期刊：
FEBS LETTERS
影响因子：
3.5
作者：
D'Avanzo, Nazzareno;Miles, Andrew J.;Powl, Andrew M.;Nichols, Colin G.;Wallace, B. A.;O'Reilly, Andrias O.
通讯作者：
O'Reilly, Andrias O.

Thermal melt circular dichroism spectroscopic studies for identifying stabilising amphipathic molecules for the voltage-gated sodium channel NavMs.