Controlling chemical reactions via pH-switchable electrostatic catalysis

通过 pH 可切换的静电催化控制化学反应

• 批准号: FL170100041
• 负责人: Prof Michelle Coote
• 金额: $ 141.64万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-12-01 至 2022-12-27
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL170100041
• 关键词: Controlling; chemical; reactions; via; pH

This project aims to establish a new approach to catalysis using the electrostatic effects of pH-switchable, charged functional groups. Utilising simple homogeneous catalysts and polymer-supported enzyme-mimicking catalysts, a wide range of target reactions will be studied. The expected outcomes of the project will include a new approach to the design and optimisation of several new classes of catalyst for assembling complex molecules and materials. The project also offers a unique opportunity to train the next generation of chemists in the principles of computer-aided chemical design. The catalysts developed in this project will be able to accelerate and control the chemical reactions used in the synthesis of pharmaceuticals and materials, with significant practical benefits to industry.

该项目旨在利用pH可切换的带电官能团的静电效应建立一种新的催化方法。利用简单的均相催化剂和聚合物负载的酶模拟催化剂，将研究广泛的目标反应。该项目的预期成果将包括一种新的方法来设计和优化几种新型催化剂，用于组装复杂的分子和材料。该项目还提供了一个独特的机会来培训下一代化学家了解计算机辅助化学设计的原理。该项目开发的催化剂将能够加速和控制药物和材料合成中使用的化学反应，对工业具有重大的实际效益。