ULTRASONIC ABSORPTION BY BIOLOGICAL MEDIA

生物介质的超声波吸收

• 批准号: 3188899
• 负责人: FLOYD DUNN
• 金额: $ 13.57万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3188899
• 关键词: bone; cell type; embryo /fetus; laboratory mouse; liposomes; lung; ovary; sonar; sound impedance; swine; tissues; ultrasonography; ultrasound biological effect

The long term objectives of the proposed research program are detailed understanding of the ultrasonic propagation properties of biological systems. Measurements are made of absorption, attenuation, and velocity of ultrasonic waves in tissues, both in vivo and in vitro, and in model systems. Continued development of appropriate instrumentation for obtaining the necessary experimental data is also pursued. The attainment of these objectives contribute to the elucidation of the physical mechanisms at all structural levels of interaction of high frequency sound in biolgical systems, considered essential for the full potential of the ultransonic techniques to be realized for medical diagnostic and therapeutic applications and for biochemical and biophysical investigations of fast reactions. The results of these investigations contribute information immediately applicable to questions regarding toxic effects, dosimetry of clinical ultrasound, efficacy of therapeutic applications, and risk assessment of diagnostic applications. Particular attention will be devoted to studying properties of fetal bone, ovary, lung, and aqueous suspensions of liposomes (as models of biological cells in suspension), during the proposed grant period.

拟议研究计划的长远目标是 详细了解超声波的传播特性 生物系统。 测量是由吸收， 衰减和超声波在组织中的速度， 体内和体外，以及模型系统。 持续发展 适当的仪器，以获得必要的 实验数据也被追踪。 实现这些 目标有助于阐明物理 在所有结构层次的相互作用机制的高 生物系统中的声音频率，被认为是 超声波技术的全部潜力将被实现， 医疗诊断和治疗应用， 快速反应的生物化学和生物物理研究。 的 这些调查的结果立即提供信息 适用于有关毒性效应、 临床超声、治疗应用的有效性和风险 诊断应用评估。 将特别注意 致力于研究胎儿骨、卵巢、肺的特性， 脂质体的水悬浮液（作为生物细胞的模型， （三）在拟批准的期限内。

项目成果

Ultrasonic absorption frequency dependence of two widely used anti-cancer drugs: doxorubicin and daunorubicin.

两种广泛使用的抗癌药物：阿霉素和柔红霉素的超声波吸收频率依赖性。

• DOI: 10.1016/0041-624x(93)90054-4
• 发表时间: 1993
• 期刊: Ultrasonics
• 影响因子: 4.2
• 作者: Tata,DB;Hahn,G;Dunn,F
• 通讯作者: Dunn,F

The effects of A23187 on the phospholipid phase transition of large unilamellar vesicles (LUVs) as detected by ultrasound spectroscopy.

超声光谱检测到 A23187 对大单层囊泡 (LUV) 磷脂相变的影响。

• DOI: 10.1016/0005-2736(90)90395-5
• 发表时间: 1990
• 期刊: Biochimica et biophysica acta
• 作者: Ma,LD;Magin,RL;Dunn,F
• 通讯作者: Dunn,F