ULTRASONIC ABSORPTION BY BIOLOGICAL MEDIA

生物介质的超声波吸收

• 批准号: 3188895
• 负责人: FLOYD DUNN
• 金额: $ 12.9万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3188895
• 关键词: bone; cell type; embryo /fetus; laboratory mouse; liposomes; lung; ovary; sonar; sound impedance; swine; tissues; ultrasonography; ultrasound biological effect

The long term objectives of the proposed research program are detailed understanding of the ultrasonic propagation properties of biological systems. Measurements are made of absorption, attenuation, and velocity of ultrasonic waves in tissues, both in vivo and in vitro, and in model systems. Continued development of appropriate instrumentation for obtaining the necessary experimental data is also pursued. The attainment of these objectives contribute to the elucidation of the physical mechanisms at all structural levels of interaction of high frequency sound in biolgical systems, considered essential for the full potential of the ultransonic techniques to be realized for medical diagnostic and therapeutic applications and for biochemical and biophysical investigations of fast reactions. The results of these investigations contribute information immediately applicable to questions regarding toxic effects, dosimetry of clinical ultrasound, efficacy of therapeutic applications, and risk assessment of diagnostic applications. Particular attention will be devoted to studying properties of fetal bone, ovary, lung, and aqueous suspensions of liposomes (as models of biological cells in suspension), during the proposed grant period.

拟议研究计划的长期目标是 对超声波传播特性的详细了解 生物系统。测量是通过吸收来进行的， 超声波在组织中的衰减和速度，两者都是 在体内和体外，以及在模型系统中。可持续发展 适当的仪器设备，以获得必要的 本文还对实验数据进行了研究。实现这些目标 目标有助于阐明物理 HIGH在所有结构层次上的相互作用机制 生物系统中的频率声，被认为是 超音速技术的全部潜力将为 医疗诊断和治疗应用以及 快速反应的生化和生物物理研究。这个 这些调查的结果立即提供了信息 适用于有关毒性效应、剂量测定的问题 临床超声、治疗应用的有效性和风险 诊断应用程序的评估。我们将特别注意 致力于研究胎儿骨骼、卵巢、肺和 脂质体的水悬浮液(作为生物细胞的模型 暂停)，在拟议的赠款期限内。