EFFECTS OF ULTRASONIC RADIATION ON FETAL GONADS

超声波辐射对胎儿性腺的影响

• 批准号: 3320715
• 负责人: FLOYD DUNN
• 金额: $ 10.73万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3320715
• 关键词: diagnosis design /evaluation; diagnosis procedure safety; embryo /fetus; gonads; laboratory mouse; ultrasonography; ultrasound biological effect; ultrasound therapy; whole body irradiation effect

It is the purpose of this study to determine the degree and nature of the morphological effects that could be produced, by low megaherz ultrasound, to fetal gonadal development. As ultrasound is widely used clinically, both in diagnosis and in therapy visceral organs have the opportunity to receive substantial exposure. Although deleterious biological effects have not been reported following clinical diagnostic usage, it is also not possible to state, unequivocally, that biological effects of ultrasound cannot occur. An area in which considerable patient exposure occurs is in the examination of the gravid uterus. Such diagnostic ultrasound exposures have now involved millions of people, with nearly half of all pregnant women in the United States now being scanned for obstetric purposes, such that a significant fraction of our future population will have been exposed to ultrasound prior to birth. Although effects to the fetus have not been reported, subtle effects have not been studied. It is the purpose of the present study to inquire whether fetal gonadal development can be affected by low level ultrasound. A preliminary study showed that 1 MHz ultrasound exposures at 10 W/cm2 for 10 sec affected fetal gonads. The proposed study will involve determining thresholds at which structural changes occur to fetal murine gonads. Following identification of ultrasound thresholds at which structural changes occur to fetal murine gonads. Following identification of ultrasound thresholds at which irreversible effects occur, light and electron microscopy of fetal gonads will be investigated. The results of this study will provide a basis for assessing risk incurred by fetal gonadal structures during exposure to ultrasound at both therapeutic and diagnostic procedures.

本研究的目的是确定其程度和性质 的形态影响，可以产生，由低 兆赫兹超声波，胎儿性腺发育。 作为 超声在临床上广泛用于诊断和治疗， 治疗内脏器官有机会接受 大量暴露。 虽然有害的生物效应 在临床诊断使用后未报告， 可以明确地说， 超声波不能发生。 在这个领域， 暴露发生在检查妊娠子宫时。 等 诊断超声暴露现在涉及数百万 美国近一半的孕妇 目前正在进行产科扫描的国家， 我们未来人口的很大一部分 在出生前接触超声波。 虽然影响到 胎儿尚未报告，微妙的影响尚未被 研究了 本研究的目的是探讨 胎儿性腺发育受低水平 超声. 一项初步研究表明，1 MHz超声波 以10 W/cm 2照射10秒影响胎儿性腺。 的 拟议的研究将涉及确定阈值， 胎鼠性腺发生结构变化。 以下 识别结构变化的超声阈值 发生在鼠胚胎的性腺上。 在确定了 发生不可逆效应的超声阈值，光 并对胎儿性腺进行电子显微镜检查。 的 这项研究的结果将为评估风险提供依据 胎儿性腺结构在暴露于超声期间， 治疗和诊断程序。