ULTRASONIC ABSORPTION BY BIOLOGICAL MEDIA

生物介质的超声波吸收

• 批准号: 3188897
• 负责人: FLOYD DUNN
• 金额: $ 12.6万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3188897
• 关键词: bone; cell type; embryo /fetus; laboratory mouse; liposomes; lung; ovary; sonar; sound impedance; swine; tissues; ultrasonography; ultrasound biological effect

The long term objectives of the proposed research program are detailed understanding of the ultrasonic propagation properties of biological systems. Measurements are made of absorption, attenuation, and velocity of ultrasonic waves in tissues, both in vivo and in vitro, and in model systems. Continued development of appropriate instrumentation for obtaining the necessary experimental data is also pursued. The attainment of these objectives contribute to the elucidation of the physical mechanisms at all structural levels of interaction of high frequency sound in biolgical systems, considered essential for the full potential of the ultransonic techniques to be realized for medical diagnostic and therapeutic applications and for biochemical and biophysical investigations of fast reactions. The results of these investigations contribute information immediately applicable to questions regarding toxic effects, dosimetry of clinical ultrasound, efficacy of therapeutic applications, and risk assessment of diagnostic applications. Particular attention will be devoted to studying properties of fetal bone, ovary, lung, and aqueous suspensions of liposomes (as models of biological cells in suspension), during the proposed grant period.

拟议研究计划的长期目标是 详细了解超声波的传播特性 生物系统。 测量由吸收率、 超声波在组织中的衰减和速度，都在 体内和体外以及模型系统。 持续发展 适当的仪器以获得必要的 还追求实验数据。 这些的实现 目标有助于阐明物理 高相互作用的所有结构层面的机制 生物系统中的频率声音，被认为对于生物系统至关重要 超声波技术的全部潜力得以实现 医疗诊断和治疗应用以及 快速反应的生物化学和生物物理研究。 这 这些调查的结果立即提供信息 适用于有关毒性作用、剂量测定的问题 临床超声、治疗应用的功效和风险 诊断应用的评估。 会特别注意 致力于研究胎儿骨骼、卵巢、肺等的特性 脂质体的水悬浮液（作为生物细胞的模型） 暂停），在拟议的拨款期内。