EFFECTS OF ULTRASONIC RADIATION ON FETAL GONADS

超声波辐射对胎儿性腺的影响

基本信息

  • 批准号:
    3320713
  • 负责人:
  • 金额:
    $ 12.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1987
  • 资助国家:
    美国
  • 起止时间:
    1987-09-01 至 1995-03-31
  • 项目状态:
    已结题

项目摘要

The clinical use of ultrasound for examination of the fetus has been available for nearly three decades. Because no deleterious effects have been detected in the exposed population, lack of risk has been assumed. However, the existence of subtle effects cannot be precluded. The initial study, "Study of Effects of Ultrasound Radiation of Fetal Gonads," was undertaken to determine if such effects occur in the fetal gonad following in utero exposure to 1 MHz ultrasound. Results of this study showed that adverse effects occurred in the fetal testis subjected to doses of ultrasound which have clinical relevance. These effects have the potential to cause reduced fertility or sterility in the adult animal. It is the purpose of this proposed study to determine the extend of these effects in the adult animal and to assess the role of heat and the resulting stress in the physical mechanism of interaction. To assess effects in the adult, experimental animals will receive in utero ultrasound exposure, be raised to maturity, and the testes subjected to extensive morphometric and histopathological analyses. Findings will be compared to data from sham and cage control specimens. The endpoints analyzed will give specific information regarding the aspect of testicular development which has been altered. The mechanism of heat will be investigated by quantifying histopathological data from testes of fetal mice heated by ultrasonic absorption and heated by a completely different thermal source. The contribution of stress as determined by increased corticosterone concentrations in the dam will also be assessed as imbalance in this hormone in fetal life is known to cause severe reproductive consequences in the adult male. To determine this, quantitative histopathological data from fetuses whose mothers received injections of exogenous corticosterone will be compared to those whose mothers received in utero ultrasound exposure. Experiments will also be carried out to determine the fetal effects of 3.5 MHz focussed ultrasound and if such observed effects are passed on to progeny. The results of this study will provide further understanding of the interaction of ultrasound and the fetal testis as well as provide a basis of risk assessment to the adult who has received in utero ultrasound exposure.
超声检查胎儿的临床应用已经 近三十年来一直可用。 因为没有有害影响 如果在受影响人群中检测到,则假定没有风险。 然而,不能排除微妙影响的存在。 的 初步研究,“超声辐射对胎儿的影响研究 生殖腺,”是为了确定这种影响是否发生在胎儿 子宫内暴露于1 MHz超声后的性腺。 成果 研究表明,胎儿睾丸受到的不良影响 有临床意义的超声波剂量。 这些影响 可能导致成年人生育能力降低或不育 动物 本研究的目的是确定 在成年动物中的这些影响,并评估热的作用, 在相互作用的物理机制中产生的应力。 评估 成年实验动物在子宫内将受到的影响 超声波照射,培养至成熟,睾丸接受超声波照射, 广泛的形态测量和组织病理学分析。 数据的日期及时间为 与来自假手术和笼对照样本的数据相比。 端点 分析将提供有关方面的具体信息, 睾丸发育发生了改变 热的机制 将通过定量来自以下动物睾丸的组织病理学数据进行研究: 超声吸收加热和完全加热胎鼠 不同的热源 应力的贡献由下式确定: 还将评估母体中皮质酮浓度的增加 因为在胎儿期这种激素的不平衡会导致严重的 对成年男性的生殖影响。 为了确定这一点, 来自母亲接受了以下治疗的胎儿的定量组织病理学数据 注射外源性皮质酮将与那些 母亲在子宫内接受超声波照射。 实验也将 为确定3.5 MHz聚焦超声对胎儿的影响, 以及这些观察到的效应是否传递给后代。 的结果 这项研究将提供进一步了解的相互作用, 超声和胎儿睾丸,以及提供一个基础的风险 对接受子宫内超声照射的成人进行评估。

项目成果

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FLOYD DUNN其他文献

FLOYD DUNN的其他文献

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{{ truncateString('FLOYD DUNN', 18)}}的其他基金

INTERACTION OF INTENSE ULTRASOUND AND MALIGNANT TISSUES
强超声与恶性组织的相互作用
  • 批准号:
    3023213
  • 财政年份:
    1991
  • 资助金额:
    $ 12.88万
  • 项目类别:
ULTRASONIC ABSORPTION BY BIOLOGICAL MEDIA
生物介质的超声波吸收
  • 批准号:
    3188895
  • 财政年份:
    1988
  • 资助金额:
    $ 12.88万
  • 项目类别:
ULTRASONIC ABSORPTION BY BIOLOGICAL MEDIA
生物介质的超声波吸收
  • 批准号:
    3188897
  • 财政年份:
    1988
  • 资助金额:
    $ 12.88万
  • 项目类别:
ULTRASONIC ABSORPTION BY BIOLOGICAL MEDIA
生物介质的超声波吸收
  • 批准号:
    3188898
  • 财政年份:
    1988
  • 资助金额:
    $ 12.88万
  • 项目类别:
ULTRASONIC ABSORPTION BY BIOLOGICAL MEDIA
生物介质的超声波吸收
  • 批准号:
    3188899
  • 财政年份:
    1988
  • 资助金额:
    $ 12.88万
  • 项目类别:
EFFECTS OF ULTRASONIC RADIATION ON FETAL GONADS
超声波辐射对胎儿性腺的影响
  • 批准号:
    2198306
  • 财政年份:
    1987
  • 资助金额:
    $ 12.88万
  • 项目类别:
EFFECTS OF ULTRASONIC RADIATION ON FETAL GONADS
超声波辐射对胎儿性腺的影响
  • 批准号:
    3320715
  • 财政年份:
    1987
  • 资助金额:
    $ 12.88万
  • 项目类别:
EFFECTS OF ULTRASONIC RADIATION ON FETAL GONADS
超声波辐射对胎儿性腺的影响
  • 批准号:
    3320711
  • 财政年份:
    1987
  • 资助金额:
    $ 12.88万
  • 项目类别:
EFFECTS OF ULTRASONIC RADIATION ON FETAL GONADS
超声波辐射对胎儿性腺的影响
  • 批准号:
    3320716
  • 财政年份:
    1987
  • 资助金额:
    $ 12.88万
  • 项目类别:
BIOMEDICAL ULTRASOUND FIELD MEASUREMENT
生物医学超声场测量
  • 批准号:
    3520096
  • 财政年份:
    1987
  • 资助金额:
    $ 12.88万
  • 项目类别:
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