Manufacture of complex protein polymers for industry and medicine

工业和医药用复杂蛋白质聚合物的制造

• 批准号: BB/M018318/1
• 负责人: Jeremy Lakey
• 金额: $ 239.57万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM018318%2F1
• 关键词: Manufacture; complex; protein; polymers; industry

Modern biomedical science and clinical medicine rely increasingly upon the growth of cells outside of the body. In this way we can perform animal free experiments which are highly informative about a range of diseases including cancer, arthritis and dementia. We can also use these artificial cell cultures to make new drugs and there is a growing industry making such drugs as Herceptin for cancer and vaccines against hepatitis. Finally we now have the hope of stem cells to create a range of regenerative medicine cures for a range of conditions. In all these cases the cells are growing outside of the body and often require an external scaffolding of molecules to support their normal growth patterns. Currently these scaffolds are every expensive and of limited technical complexity. This project will create a cheap, pure and highly flexible source of polymeric proteins which can be built into a range of products to accelerate and stabilise the growth of cells in culture and assist all the technologies mentioned above.

现代生物医学和临床医学越来越依赖于体外细胞的生长。通过这种方式，我们可以进行无动物实验，这些实验对癌症，关节炎和痴呆症等一系列疾病具有高度的信息性。我们还可以利用这些人工细胞培养物来制造新药，目前有一个不断发展的行业，生产治疗癌症的赫赛汀和肝炎疫苗等药物。最后，我们现在有希望用干细胞来创造一系列再生医学疗法来治疗一系列疾病。在所有这些情况下，细胞都在体外生长，通常需要外部分子支架来支持它们的正常生长模式。目前，这些支架非常昂贵并且技术复杂性有限。该项目将创造一种廉价，纯净和高度灵活的聚合蛋白质来源，可用于一系列产品中，以加速和稳定培养中细胞的生长，并协助上述所有技术。

项目成果

A Thermally Reformable Protein Polymer

• DOI: 10.1016/j.chempr.2020.09.020
• 发表时间: 2020-11-05
• 期刊: CHEM
• 影响因子: 23.5
• 作者: Dura, Gema;Peters, Daniel T.;Fulton, David A.
• 通讯作者: Fulton, David A.

The polymer and materials science of the bacterial fimbriae Caf1.

• DOI: 10.1039/d3bm01075a
• 发表时间: 2023-11-07
• 期刊: Biomaterials science
• 影响因子: 6.6

Exploiting Meltable Protein Hydrogels to Encapsulate and Culture Cells in 3D.

利用可熔蛋白质水凝胶封装和培养 3D 细胞。

• DOI: 10.1002/mabi.202200134
• 发表时间: 2022
• 期刊: Macromolecular bioscience
• 影响因子: 4.6
• 作者: Dura G

Additional file 1: of Induction of the immunoprotective coat of Yersinia pestis at body temperature is mediated by the Caf1R transcription factor

附加文件1：鼠疫耶尔森菌免疫保护层在体温下的诱导是由Caf1R转录因子介导的

• DOI: 10.6084/m9.figshare.7915967
• 发表时间: 2019
• 作者: Abdulmajeed Al-Jawdah

The synthesis of poly(arylthiols) and their utilization in the preparation of cross-linked dynamic covalent polymer nanoparticles and hydrogels

• DOI: 10.1039/c9py00057g
• 发表时间: 2019-03
• 期刊: Polymer Chemistry
• 影响因子: 4.6
• 作者: Michael E Bracchi;Gema Durá;D. Fulton