权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Integrated micro-electrodes and micro-capillaries for the study and control of neuronal activity

用于研究和控制神经元活动的集成微电极和微毛细血管

基本信息

批准号：
BB/M019187/1
负责人：
David Steenson
金额：
$ 15.3万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FM019187%2F1
关键词：
Integrated micro electrodes capillaries study

项目摘要

Hyper-reflexia and hyper-tonicity of the muscles, commonly referred to as spasticity, is a common and debilitating phenomenon in motor disorders like stroke, spinal cord injury, multiple sclerosis or severe brain trauma. This work aims to explore a possible long term and adaptable treatment route via the exploitation of standard silicon and Micro-Electro Mechanical System (MEMS) manufacturing methods to form micron scale electrode arrays formed alongside micro-capillaries with the intention of implanting these electrodes in the brain and spine for localized stimulation and sensing. The materials and sizes will be chosen to have the least possible adverse effects and it is hoped that this can provide a long term means of receiving, stimulating and control of nerve signals after trauma such as spinal cord injury or stroke.This is technically challenging and novel and would also permit for the first time a much more detailed and comprehensive study of neuronal signals with micron precision within the spine. External stimulation both electrical and pharmacological (using directed picolitre quantities of drugs), together with electrical sensing and feedback, is unique, allowing a hitherto impossible level of manipulation, understanding and thereby control, of neurological behaviour, and without the drawbacks of systemic drug treatments. Ultimately the aim of the work will be to control pain and motor responses (and smart prosthetics) using adaptable electronic and pharmacological signals.

肌肉的反射亢进和张力过高，通常被称为痉挛，是运动障碍如中风、脊髓损伤、多发性硬化或严重脑外伤中的常见和衰弱现象。这项工作的目的是探索一种可能的长期和适应性强的治疗途径，通过利用标准的硅和微机电系统（MEMS）制造方法来形成微米级的电极阵列，这些电极阵列与微毛细管一起形成，目的是将这些电极植入大脑和脊柱中，用于局部刺激和传感。将选择具有最小可能的不良影响的材料和尺寸，并且希望这可以提供在创伤（例如脊髓损伤或中风）后接收、刺激和控制神经信号的长期手段。这在技术上具有挑战性和新颖性，并且还将首次允许对脊柱内的神经信号进行更详细和全面的研究，其精度为微米。电刺激和药理学刺激（使用定向皮升量的药物）以及电感测和反馈是独特的，允许迄今为止不可能的神经行为的操纵、理解和控制水平，并且没有全身药物治疗的缺点。这项工作的最终目标是使用可适应的电子和药理信号来控制疼痛和运动反应（以及智能假肢）。