POROUS POLYETHYLENE AND POROUS POLYSULFONE TOOTH ROOTS

多孔聚乙烯和多孔聚砜牙根

• 批准号: 3219954
• 负责人: MYRON SPECTOR
• 金额: $ 15.68万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-03-01 至 1987-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3219954
• 关键词: dental prosthesis; electron microscopy; endodontics; endosseous dental implant; malocclusion; microradiography; periodontium disorder; polyethylenes; titanium; tooth root

Results of ongoing studies substantiate the working hypothesis that the bone ingrowth into a porous polymeric coating on artificial tooth roots can serve as the attachment vehicle for free-standing endosseous dental implants. Furthermore, the results have demonstrated that mechanical property requirements of this type of dental implant system are not met by porous high density polyethylene, but are met by porous polysulfone. The specific aims are now to: 1) quantitively evaluate histological changes with time in bone and gingiva around clinically successful porous polysulfone-coated artificial tooth roots through five years of implantation, 2) construct a survival curve for this implant serving as a free-standing mandibular, posterior tooth in occlusion, and 3) determine the load-carrying capacity of the artificial tooth roots three months and two years after implantation. The Rhesus monkey is the experimental animal model. Porous polysulfone-coated artificial tooth roots of the type presently being investigated will be implanted in healed, mandibular premolar extraction sites in Rhesus monkeys. Each animal will receive two implants. In a first series of animals five implants will be retrieved by block resection after each of the following time periods: 1, 3, 6, 12, and 24 months after placement of transgingival abutments to the submucosal roots. Five other implants will be retrieved at the submucosal stage prior to placement of the implants in function. This totals 30 implants retrieved from 15 animals. A second series of eight implants will be mechanically tested to determine the load-carrying capability of the implants 3 and 24 months after placement of the transgingival abutments. Finally, a group of six monkeys will be continued from the ongoing study to eventually yield implants of five-years duration. Histomorphometric analyses will be performed on undecalcified microtome sections using a semi-automated image anaalysis system. Survival analysis of the "censored data" will be performed to generate a survival curve and to determine the "time-to-failure". A correlation of the histology, mechanical test data, and the survival data will be made.

正在进行的研究结果证实了工作假设， 骨向内生长到人造牙根上的多孔聚合物涂层中可以 作为独立式骨内牙科的附着载体 植入物. 此外，结果表明，机械 这种类型的牙科植入物系统的性能要求不能通过 多孔高密度聚乙烯，但多孔聚砜满足。 的 目前的具体目标是：1）定量评价组织学变化 随着时间的推移，在骨和牙龈周围临床成功的多孔 聚砜涂层人工牙根通过五年的 植入，2）构建该植入物的存活曲线， 独立的下颌，咬合中的后牙，以及3）确定 人工牙根的承载能力，3个月， 植入后两年。 恒河猴是实验动物 模型 多孔聚砜涂层人工牙根 目前正在研究的将植入愈合的下颌骨， 恒河猴的前磨牙拔除部位。 每只动物将获得两个 植入物. 在第一组动物中，将通过以下方法取出5个植入物： 在以下每个时间段后进行块切除：1、3、6、12和 跨龈基台放置到粘膜下后24个月 根 其他五个植入物将在粘膜下阶段取出， 植入物的功能。 共植入30枚 从15只动物身上提取。 第二个系列的8个植入物将 进行机械测试，以确定 种植体植入后3个月和24个月的跨龈基台。 最后，一组6只猴将继续进行正在进行的研究， 最终生产出五年寿命的植入物。 形态计量 将使用未脱钙切片机切片进行分析， 半自动图像分析系统。 “删失”的生存分析 将进行“数据”分析以生成生存曲线并确定 “故障时间”。 组织学、机械测试数据， 生存数据也就出来了。