CALCIUM PHOSPHATE COATING FOR ORTHOPEDIC PROSTHESES

用于骨科假肢的磷酸钙涂层

• 批准号: 2080054
• 负责人: MYRON SPECTOR
• 金额: $ 34.25万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-20 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2080054
• 关键词: Mammalia; bone prosthesis; calcium phosphate; chemical bond; electron microscopy; histology; hydroxyapatites; joint prosthesis; normal ossification; orthopedics; stoichiometry; surface property

DESCRIPTION: (Adapted from investigator's abstract) The long-term objective of this research is to better understand the mechanisms underlying the bonding of bone to calcium-containing substances so that efficacious coatings for joint replacement prostheses can be developed. "Bone bonding" is inferred from: (a) histology and electron microscopy that reveal bone matrix deposited directly on the surface of the calcium-containing implant; and (b) strengths of attachment that cannot be explained by bone apposition alone. The specific research described in this application is intended to test the hypothesis that bone bonding is facilitated by the precipitation of biological apatite onto the calcium-containing implant. This deposition of apatite, similar to the carbonate apatite comprising bone mineral, begins within days of implantation and presumably favors subsequent protein adsorption and bone cell attachment. The investigators postulate that the rate of apatite precipitation and bone formation on calcium-containing substances can be correlated with surface chemistry and crystalline structure, with the most favorable substrate being the one that most closely resembles bone mineral. The applicants hope to show that biological apatite will precipitate onto a metallic surface into which calcium ions have been implanted. They expect that this apatite deposition and subsequent bone bonding proceeds at a slower rate than with calcium phosphates more closely resembling bone mineral. However, the calcium-ion- implanted surface may have mechanical advantages over other substance, warranting its investigation.

描述：（改编自研究者摘要）长期 这项研究的目的是更好地了解机制 是骨骼与含钙物质结合的基础， 可以开发用于关节置换假体的有效涂层。 “骨结合”从以下方面推断：（a）组织学和电子显微镜 显示骨基质直接沉积在 含钙植入物;和（B）不能 仅通过骨沉积来解释。 中描述的具体研究 本申请旨在检验骨结合 通过将生物磷灰石沉淀到 含钙植入物 这种磷灰石的沉积，类似于 包括骨矿物质的碳酸磷灰石，开始于 植入，并可能有利于随后的蛋白质吸附和骨 细胞附着 研究人员假设磷灰石的含量 含钙物质上的沉淀和骨形成， 与表面化学和晶体结构相关， 有利的基质是与骨最相似的基质 矿物质 申请人希望证明生物磷灰石 沉淀到金属表面上，其中钙离子已经被 植入的 他们预计这种磷灰石沉积和随后的骨骼 粘结的速度比磷酸钙慢， 与骨矿物质非常相似。然而， 表面可能比其他物质具有机械优势， 其调查。

项目成果

Pre-conditioning and dual constant composition dissolution kinetics of pulsed laser deposited hydroxyapatite thin films on silicon substrates.

• DOI: 10.1016/0142-9612(96)88714-x
• 发表时间: 1996-03
• 期刊: Biomaterials
• 影响因子: 14
• 作者: B. E. Tucker;C. M. Cottell;R.C.Y. Auyeungt;M. Spector;G. H. Nancollas

Dual constant composition kinetics characterization of apatitic surfaces.

磷灰石表面的双常数组成动力学表征。

• DOI: 10.1002/jbm.820281205
• 发表时间: 1994
• 期刊: Journal of biomedical materials research
• 作者: Paschalis,EP;Wikiel,K;Nancollas,GH
• 通讯作者: Nancollas,GH

Degradation potential of plasma-sprayed hydroxyapatite-coated titanium implants.

等离子喷涂羟基磷灰石涂层钛植入物的降解潜力。

• DOI: 10.1002/jbm.820291206
• 发表时间: 1995
• 期刊: Journal of biomedical materials research.
• 作者: Paschalis,EP;Zhao,Q;Tucker,BE;Mukhopadhayay,S;Bearcroft,JA;Beals,NB;Spector,M;Nancollas,GH
• 通讯作者: Nancollas,GH