CALCIUM PHOSPHATE COATING FOR ORTHOPEDIC PROSTHESES

描述：(改编自调查人员摘要)长期 本研究的目的是为了更好地了解其发病机制。 骨与含钙物质之间的粘合作用 可以开发出用于关节置换假体的有效涂层。 “骨结合”是从：(A)组织学和电子显微镜推断出来的 揭示了沉积的骨基质 直接在含钙植入物的表面上；和(B) 强项 不能仅用骨头对位来解释的依恋。这个 专一 本申请中描述的研究旨在检验该假设 那 生物磷灰石的沉淀促进了骨的结合 vt.上 含钙植入物。这种磷灰石的沉积，类似于 这个 由骨矿组成的碳酸盐磷灰石，在几天内开始 植入 可能有利于随后的蛋白质吸附和骨细胞 依恋。 研究人员推测，磷灰石沉淀的速度和 骨 含钙物质的形成可以与 曲面 化学和晶体结构，具有最有利的衬底 是最接近骨矿物质的。申请者 希望展示生物磷灰石会沉淀到金属上 注入了钙离子的表面。他们期待着 这种磷灰石沉积和随后的骨结合进行得较慢。 速度比磷酸钙更接近骨矿物质。 然而，钙离子注入的表面可能具有机械性能 相对于其他物质的优势，有理由对其进行调查。

DESCRIPTION: (Adapted from investigator's abstract) The long-term objective of this research is to better understand the mechanisms underlying the bonding of bone to calcium-containing substances so that efficacious coatings for joint replacement prostheses can be developed. "Bone bonding" is inferred from: (a) histology and electron microscopy that reveal bone matrix deposited directly on the surface of the calcium-containing implant; and (b) strengths of attachment that cannot be explained by bone apposition alone. The specific research described in this application is intended to test the hypothesis that bone bonding is facilitated by the precipitation of biological apatite onto the calcium-containing implant. This deposition of apatite, similar to the carbonate apatite comprising bone mineral, begins within days of implantation and presumably favors subsequent protein adsorption and bone cell attachment. The investigators postulate that the rate of apatite precipitation and bone formation on calcium-containing substances can be correlated with surface chemistry and crystalline structure, with the most favorable substrate being the one that most closely resembles bone mineral. The applicants hope to show that biological apatite will precipitate onto a metallic surface into which calcium ions have been implanted. They expect that this apatite deposition and subsequent bone bonding proceeds at a slower rate than with calcium phosphates more closely resembling bone mineral. However, the calcium-ion- implanted surface may have mechanical advantages over other substance, warranting its investigation.