CALCIUM PHOSPHATE COATING FOR ORTHOPEDIC PROSTHESES

用于骨科假肢的磷酸钙涂层

• 批准号: 3160795
• 负责人: MYRON SPECTOR
• 金额: $ 40.28万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-20 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3160795
• 关键词: Mammalia; bone prosthesis; calcium phosphate; chemical bond; electron microscopy; histology; hydroxyapatites; joint prosthesis; normal ossification; orthopedics; stoichiometry; surface property

DESCRIPTION: (Adapted from investigator's abstract) The long-term objective of this research is to better understand the mechanisms underlying the bonding of bone to calcium-containing substances so that efficacious coatings for joint replacement prostheses can be developed. "Bone bonding" is inferred from: (a) histology and electron microscopy that reveal bone matrix deposited directly on the surface of the calcium-containing implant; and (b) strengths of attachment that cannot be explained by bone apposition alone. The specific research described in this application is intended to test the hypothesis that bone bonding is facilitated by the precipitation of biological apatite onto the calcium-containing implant. This deposition of apatite, similar to the carbonate apatite comprising bone mineral, begins within days of implantation and presumably favors subsequent protein adsorption and bone cell attachment. The investigators postulate that the rate of apatite precipitation and bone formation on calcium-containing substances can be correlated with surface chemistry and crystalline structure, with the most favorable substrate being the one that most closely resembles bone mineral. The applicants hope to show that biological apatite will precipitate onto a metallic surface into which calcium ions have been implanted. They expect that this apatite deposition and subsequent bone bonding proceeds at a slower rate than with calcium phosphates more closely resembling bone mineral. However, the calcium-ion- implanted surface may have mechanical advantages over other substance, warranting its investigation.

描述：（改编自研究者摘要）长期 这项研究的目的是更好地了解机制 是骨骼与含钙物质结合的基础， 可以开发用于关节置换假体的有效涂层。 “骨结合”从以下方面推断：（a）组织学和电子显微镜 显示了骨基质沉积在 直接在含钙植入物的表面上;和（B） 优势 不能仅仅用骨附着来解释的连接。 的 具体 本申请中描述的研究旨在检验假设 的 通过生物磷灰石的沉淀促进骨结合 到 含钙植入物 这种磷灰石的沉积，类似于 的 包括骨矿物质的碳酸磷灰石，开始于 植入 并可能有利于随后的蛋白质吸附和骨细胞 附件. 研究人员假设磷灰石沉淀的速率和 骨 含钙物质的形成可能与 表面 化学和晶体结构，最有利的基板 与骨矿物质最为相似。申请人 希望证明生物磷灰石会沉淀到金属上， 钙离子被注入的表面。 他们预计 这种磷灰石沉积和随后的骨结合以较慢的速度进行 比磷酸钙更接近骨矿物质。 然而，钙离子注入表面可具有机械特性。 与其他物质相比，它具有许多优点，因此，它的研究是必要的。