CALCIUM PHOSPHATE COATING FOR ORTHOPEDIC PROSTHESES

描述：(改编自调查人员摘要)长期 本研究的目的是为了更好地了解其发病机制。 骨与含钙物质之间的粘合作用 可以开发出用于关节置换假体的有效涂层。 “骨结合”是从：(A)组织学和电子显微镜推断出来的 揭示了直接沉积在骨表面的骨基质 含钙植入物；以及(B)不能 仅用骨头对位来解释的。中描述的具体研究 此应用程序旨在测试以下假设：骨结合 促进了生物磷灰石的沉淀 含钙植入物。这种磷灰石的沉积，类似于 由骨矿组成的碳酸盐磷灰石，在几天内开始 并推测有利于随后的蛋白质吸附和骨骼 细胞附着。调查人员推测，磷灰石的比例 含钙物质上的沉淀和骨形成可以 与表面化学和晶体结构相关，与大多数 有利的底物是与骨骼最相似的底物 矿物。申请者希望展示生物磷灰石将 沉淀到钙离子已经进入的金属表面上 被植入体内。他们预计这种磷灰石沉积和随后的骨骼 与磷酸钙相比，粘合的速度更慢 与骨矿物质非常相似。然而，钙离子注入 表面可能比其他物质具有机械优势，保证 它的调查。

DESCRIPTION: (Adapted from investigator's abstract) The long-term objective of this research is to better understand the mechanisms underlying the bonding of bone to calcium-containing substances so that efficacious coatings for joint replacement prostheses can be developed. "Bone bonding" is inferred from: (a) histology and electron microscopy that reveal bone matrix deposited directly on the surface of the calcium-containing implant; and (b) strengths of attachment that cannot be explained by bone apposition alone. The specific research described in this application is intended to test the hypothesis that bone bonding is facilitated by the precipitation of biological apatite onto the calcium-containing implant. This deposition of apatite, similar to the carbonate apatite comprising bone mineral, begins within days of implantation and presumably favors subsequent protein adsorption and bone cell attachment. The investigators postulate that the rate of apatite precipitation and bone formation on calcium-containing substances can be correlated with surface chemistry and crystalline structure, with the most favorable substrate being the one that most closely resembles bone mineral. The applicants hope to show that biological apatite will precipitate onto a metallic surface into which calcium ions have been implanted. They expect that this apatite deposition and subsequent bone bonding proceeds at a slower rate than with calcium phosphates more closely resembling bone mineral. However, the calcium-ion- implanted surface may have mechanical advantages over other substance, warranting its investigation.