POROUS POLYETHYLENE AND POROUS POLYSULFONE TOOTH ROOTS

多孔聚乙烯和多孔聚砜牙根

• 批准号: 3219955
• 负责人: MYRON SPECTOR
• 金额: $ 15.54万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-03-01 至 1987-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3219955
• 关键词: dental prosthesis; electron microscopy; endodontics; endosseous dental implant; malocclusion; microradiography; periodontium disorder; polyethylenes; titanium; tooth root

Results of ongoing studies substantiate the working hypothesis that the bone ingrowth into a porous polymeric coating on artificial tooth roots can serve as the attachment vehicle for free-standing endosseous dental implants. Furthermore, the results have demonstrated that mechanical property requirements of this type of dental implant system are not met by porous high density polyethylene, but are met by porous polysulfone. The specific aims are now to: 1) quantitively evaluate histological changes with time in bone and gingiva around clinically successful porous polysulfone-coated artificial tooth roots through five years of implantation, 2) construct a survival curve for this implant serving as a free-standing mandibular, posterior tooth in occlusion, and 3) determine the load-carrying capacity of the artificial tooth roots three months and two years after implantation. The Rhesus monkey is the experimental animal model. Porous polysulfone-coated artificial tooth roots of the type presently being investigated will be implanted in healed, mandibular premolar extraction sites in Rhesus monkeys. Each animal will receive two implants. In a first series of animals five implants will be retrieved by block resection after each of the following time periods: 1, 3, 6, 12, and 24 months after placement of transgingival abutments to the submucosal roots. Five other implants will be retrieved at the submucosal stage prior to placement of the implants in function. This totals 30 implants retrieved from 15 animals. A second series of eight implants will be mechanically tested to determine the load-carrying capability of the implants 3 and 24 months after placement of the transgingival abutments. Finally, a group of six monkeys will be continued from the ongoing study to eventually yield implants of five-years duration. Histomorphometric analyses will be performed on undecalcified microtome sections using a semi-automated image anaalysis system. Survival analysis of the "censored data" will be performed to generate a survival curve and to determine the "time-to-failure". A correlation of the histology, mechanical test data, and the survival data will be made.

正在进行的研究结果证实了工作假说 人工牙根上的多孔聚合物涂层中的骨长入可以 作为独立的骨内牙科附着载体 植入物。此外，结果还表明，机械 这种类型的牙种植体系统的性能要求不符合 多孔高密度聚乙烯，但满足多孔聚砜。这个 现在的具体目标是：1)定量评估组织学变化 随着时间的推移，在骨和牙龈周围的临床成功多孔性 聚砜涂层人工牙根通过五年的 植入，2)构建该植入物的存活曲线，作为 自立式下颌、后牙合和3)确定 人工牙根3个月和3个月的承载能力 植入两年后。恒河猴是实验动物 模特。多孔型聚砜涂层人工牙根 目前正在研究的是将种植在愈合的，下颌 恒河猴的前磨牙拔除部位。每只动物将得到两只 植入物。在第一组动物中，五个种植体将被取回 在以下每个时间段之后进行块切除：1、3、6、12和 经牙周基牙植入黏膜下24个月后 树根。另外五个植入物将在之前的粘膜下阶段被取回 植入物在功能上的放置。总共有30颗植入物 取自15只动物。第二个系列的八个植入物将是 经过机械测试，以确定其承载能力 种植后3个月和24个月后，经牙周基牙。 最后，一组六只猴子将从正在进行的研究中继续下去 最终产生为期五年的植入物。组织形态计量学 分析将在未脱钙的切片上使用 半自动图像分析系统。《审查者》的生存分析 将执行“数据”以生成生存曲线并确定 “失败的时间”。组织学，机械测试数据， 存活期数据将会被制作出来。