COCAINE & BEHAVIOR: ORAL ABUSE & MOTOR CONTROL

这项提案研究口服可卡因的行为药理学 自我管理。 诱导的最佳条件 通过不同的药物， 浓度和食物时间表诱导参数， 会产生过激行为 一般的效果是- 使用和滥用合法药物（尼古丁和咖啡因）可能会 将确定增加时间表诱导的可卡因摄入量， 以及有前途的治疗药物的可能的衰减作用， （地昔帕明）和封闭剂（例如，氯丙嗪和 匹莫齐特）。 将对一些商品和活动进行测试 作为可卡因的行为替代品， 产生过度行为的条件 广泛接触 以前使用非药物的经验，高度首选的物质，如 糖精（然后变得不可用）， 这可能会阻碍其发展， 可以预先适应诱导条件。 的可能性 先前过量摄入尼古丁或咖啡因 将探讨可卡因滥用的发展。 的影响 在精细运动控制任务上的胃肠外可卡因注射将是 确定，以及咖啡因和咖啡因的相互作用， 尼古丁和长期可卡因对这种表现的影响。 血清 可卡因和代谢物水平将与行为相关 方面的影响.

This proposal studies the behavioral pharmacology of oral cocaine self-administration. The optimal conditions for the induction of cocaine overindulgence in rats will be established by varying drug concentration and the food-schedule induction parameters which are known to produce excessive behaviors. The effect commonly- used and abuse licit agents (nicotine and caffeine) might have in increasing schedule-induced cocaine intake will be determined, as well as possible attenuating effects of promising therapeutic (desipramine) and blocking agents (e.g., chlorpromazine and pimozide). A number of commodities and activities will be tested as behavioral alternatives to available cocaine under the excessive-behavior-generating conditions. Extensive exposure to prior experiences with non-drug, highly-preferred substances such as saccharin (which are then made unavailable) under conditions that should induce cocaine abuse may block its development, as may pre-adaptation to the inducing conditions. The possibility that prior overindulgence of nicotine or caffeine may predispose to cocaine abuse development will be explored. The effect of parenteral cocaine injection on a fine motor control task will be determined, as well as the interactive effects of caffeine and of nicotine with chronic cocaine on this kind of performance. Serum cocaine and metabolite levels will be correlated with behavioral effects.