3-D ANALYSIS OF AUDITORY BRAINSTEM RESPONSE IN HUMANS

人类听觉脑干反应的 3D 分析

• 批准号: 3216582
• 负责人: Don L. Jewett
• 金额: $ 32.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3216582
• 关键词: auditory pathways; auditory stimulus; brain stem; cochlear nerve; diagnosis quality /standard; electrodes; evoked potentials; hearing tests; human subject; stimulus /response

The overall goal of this project is to advance basic science knowledge of the ABR (Auditory Brainstem Response), recorded in humans, based upon recent developments in multi-channel recordings. Several lines of research will be pursued. First, it will be determined whether the ABR in humans, in whole or in part, can be modelled as an equivalent dipole. Humans will be studied recording from electrodes placed on the scalp according to the standard 10-20 system. Two lines of evidence will be used to determine if the potentials are consistent with an eccentric dipole generator: a) comparison of the dipole generator estimated from two different electrode arrays. b) comparison of the surface potential distribution of the ABR at each point in time, with potentials recorded from dipoles placed in a volume-conductor molded from the head of the subject. The testing of surface potential distribution related to a dipole in the internal auditory meatus will also contribute to the question as to whether wave II of the ABR is due to the VIIIth nerve action potential entering the cranium. Second, the effects of signal filters on the ABR waveforms will be studied as they affect the orientation, magnitude, or detection of the equivalent dipole. Third, the effects of muscle artifacts on the potentials recorded at different scalp locations will be determined, as well as whether nearfield muscle recordings provide a better means of excluding artifact-containing sweeps. Finally, the signal-to-noise ratio of different electrode locations for recording the ABR in humans will be studied in order to determine the optimal locations for electrodes. This research is directly related to the medical uses of the ABR, which includes diagnosis of hearing deficits in newborns, infants, and adults, as well as diagnosis of neurological abnormalities in children and adults.

该项目的总体目标是提高基础科学知识 人类记录的 ABR（听觉脑干反应） 多通道录音的最新发展。几条研究方向 将被追捕。首先，将确定人类中的 ABR 是否存在 全部或部分，可以建模为等效偶极子。人类将会 研究了放置在头皮上的电极的记录 标准10-20系统。将使用两条证据来确定是否 电势与偏心偶极子发生器一致：a) 从两个不同电极估计的偶极子发生器的比较 数组。 b) ABR 表面电位分布比较 每个时间点，从放置在一个偶极子中记录电势 由对象头部模制而成的体积导体。的测试 与内听觉偶极子相关的表面电位分布 外道也将有助于解答第二波浪潮是否 ABR 是由于第八神经动作电位进入颅骨。 其次，将研究信号滤波器对ABR波形的影响 因为它们会影响等效物的方向、大小或检测 偶极子。 第三，肌肉伪影对记录电位的影响 将确定不同的头皮位置，以及是否近场 肌肉记录提供了更好的方法来排除含有伪影的 扫荡。 最后，不同电极位置的信噪比 将研究在人类中记录 ABR 以确定 电极的最佳位置。 这项研究与 ABR 的医疗用途直接相关， 包括新生儿、婴儿和成人听力缺陷的诊断，例如 以及儿童和成人神经系统异常的诊断。