AGE DEPENDENT FACTORS IN URETERAL-VESICAL FUNCTION

输尿管膀胱功能的年龄依赖性因素

• 批准号: 3237607
• 负责人: ROBERT M WEISS
• 金额: $ 20.8万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-02-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3237607
• 关键词: acetylcholine; adenylate cyclase; adrenergic agents; aging; animal old age; carbachol; cyclic AMP; drug metabolism; histamine; hormone regulation /control mechanism; isoproterenol; juvenile animal; kidney function; kidney pharmacology; muscle contraction; newborn animals; norepinephrine; papaverine; smooth muscle; theophylline; ureter; ureter obstruction

Pathologic conditions, primarily obstruction, result in changes in ureteral length and diameter, which in turn affects the ability of the ureter to contract. Abnormalities in ureteral function may in turn lead to deterioration of renal structure and function. In addition, preliminary data have suggested that there are age dependent changes in the ureter that in themselves effect its function and that influence its response to obstruction. As an example, it is apparent clinically that obstruction results in more extensive ureteral dilatation in the neonate than in the adult. Furthermore, we have demonstrated that the neonatal rabbit ureter undergoes greater dimensional deformation in response to obstruction and has a greater sensitivity to neurohumoral agents, i.e., catacholamines, than does the adult rabbit ureter. Thus there are apparent differences in the structure and pharmacologic responses of the neonatal and adult ureter which affect their ability to function. The full extent of and reason for these age dependent variations in ureteral mechanical and pharmacological properties is not known. It is plnned to define the age related changes in the mechanical properties, and pharmacologic responses of the neonatal, adult, and elderly adult ureter. The effects of age on the interrelationships of intraluminal pressure, wall tension, length and diametral deformation, and the force and velocity of contraction will be determined. In addition, changes in the pharmacologic properties, i.e. response to neurohumoral agents, catecholamine content, endogenous cAMP levels and adenylate cyclase and phosphodiesterase activity, as affected by aging and disease will be investigated. It is hoped that this information concerning ureteral smooth muscle may give insight into methods of management of the ureter in pathologic conditions.

病理状况（主要是梗阻）导致输尿管变化 长度和直径，进而影响输尿管的能力 合同。 输尿管功能异常可能反过来导致恶化 肾的结构和功能。 此外，初步数据显示 输尿管存在与年龄相关的变化，这些变化本身会影响其 功能并影响其对阻塞的反应。 举个例子，它是 临床上明显的是，梗阻导致输尿管更广泛 新生儿的扩张程度高于成人。 此外，我们还证明了 新生兔输尿管发生较大的尺寸变形 对阻塞的反应并对神经体液药物具有更高的敏感性， 即儿茶酚胺，比成年兔输尿管的含量要高。 因此有 结构和药理反应的明显差异 新生儿和成人输尿管会影响其功能。 完整的 这些年龄相关的输尿管机械变化的程度和原因 且药理特性尚不清楚。 计划定义与年龄相关的机械性能变化，以及 新生儿、成人和老年人输尿管的药理反应。 这 年龄对腔内压力、壁张力、 长度和直径变形，以及收缩的力和速度 被确定。 此外，药理学特性的变化，即 对神经体液药物的反应、儿茶酚胺含量、内源性 cAMP 水平 以及腺苷酸环化酶和磷酸二酯酶活性，受衰老和 疾病将被调查。 希望这些信息涉及 输尿管平滑肌可能有助于深入了解输尿管的管理方法 在病理条件下。