The Human Ageing Genomic Resources

人类衰老基因组资源

• 批准号: BB/R014949/2
• 负责人: Joao Magalhaes
• 金额: $ 5.1万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FR014949%2F2
• 关键词: Human; Ageing; Genomic; Resources

Ageing is a major biomedical challenge of the 21st century and research on the biology and genetics of ageing has an unparalleled potential to improve quality of life and health. The Human Ageing Genomic Resources (HAGR) are a collection of online databases and tools designed to assist basic research on ageing. This project aims to maintain, update and enhance HAGR to sustain its world-leading status and continue serving the scientific community with high-quality data.In a remarkable series of recent breakthroughs, a number of genes capable of altering the ageing process have been identified in animal models and even a few in humans. This is a fascinating and important area of research, yet there is a tremendous number of genes being associated with ageing and longevity that keeping track of them all is becoming increasingly difficult. To help researchers address these issues we created various databases of genes related to longevity and/or ageing. Numerous researchers employ our gene databases in their work as an informational website and/or as a tool for data-mining and for interpreting experimental results.Although finding mechanisms of ageing conserved between model organisms and humans is important, the diversity of ageing rates between similar species is remarkable. Understanding why different species age at different rates may provide key insights into the mechanisms of human ageing. Also part of HAGR is a database of ageing in animals with over 4,000 species, featuring the most accurate and complete collection of longevity records available in any format. Our database is an essential resource for researchers working on comparative and evolutionary studies of ageing to identify factors or features that correlate with species longevity.The HAGR databases are widely-used by ageing researchers worldwide and have been invaluable in many different types of studies. Indeed, HAGR has been cited over 500 times. Besides, our online resources receive over 30,000 visitors per month, showcasing HAGR's importance in the field. All HAGR databases are open access and also provide users with the possibility to export, download and reuse the data for their own analyses.

老龄化是21世纪生物医学的一个重大挑战，对老龄化的生物学和遗传学研究在改善生活质量和健康方面具有无与伦比的潜力。人类老化基因组资源（HAGR）是一个在线数据库和工具的集合，旨在协助老化的基础研究。该项目旨在维护、更新和增强HAGR，以保持其世界领先地位，并继续为科学界提供高质量的数据。在最近一系列引人注目的突破中，许多能够改变衰老过程的基因已经在动物模型中被发现，甚至在人类模型中也发现了一些。这是一个迷人而重要的研究领域，然而有大量的基因与衰老和长寿有关，要追踪它们变得越来越困难。为了帮助研究人员解决这些问题，我们创建了各种与长寿和/或衰老相关的基因数据库。许多研究人员在他们的工作中使用我们的基因数据库作为信息网站和/或作为数据挖掘和解释实验结果的工具。尽管发现模式生物和人类之间保守的衰老机制很重要，但相似物种之间衰老率的多样性是显著的。理解为什么不同的物种以不同的速度衰老，可能为人类衰老的机制提供关键的见解。HAGR的另一个组成部分是一个包含超过4000种动物的衰老数据库，以任何格式提供的最准确、最完整的长寿记录为特色。我们的数据库是研究衰老的比较和进化研究的研究人员识别与物种寿命相关的因素或特征的重要资源。HAGR数据库被世界各地的老龄化研究人员广泛使用，在许多不同类型的研究中都具有不可估量的价值。事实上，HAGR被引用了500多次。此外，我们的在线资源每月接待超过30,000名访客，显示了HAGR在该领域的重要性。所有HAGR数据库都是开放访问的，并且还为用户提供了导出、下载和重用数据以供自己分析的可能性。