EXPERIMENTAL MYOPIA IN PRIMATES

灵长类动物的实验性近视

• 批准号: 3260202
• 负责人: TORSTEN N. WIESEL
• 金额: $ 11.65万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3260202
• 关键词: afferent nerve; biological models; ciliary ganglion; efferent nerve; eye accommodation; histopathology; myopia; newborn animals; superior cervical ganglion; visual deprivation

The main objectives of this project are to elucidate the mechanisms responsible for the genesis of axial myopia, and to develop procedures to treat and/or prevent the condition. The Macaque monkey will be used as an animal model because neonatal lid closure or corneal opacification produces axial myopia (-4D to -13 D) and characteristic fundus changes. Since the central nervous system plays an important role in the development of the myopia the effects of interrupting afferent and efferent pathways on the lid-closure myopia will be investigated by intracranial section of (1) the optic nerve, (2) the trigeminal nerve, and (3) oculomotor nerves. Previous work indicated that atropine administration prevents axial myopia in M. arctoides but not in M. mulatta; the role of accomodation will be further investigated by (1) removal of the ciliary ganglion, (2) electrical stimulation of the ciliary ganglion, and (3) forced accomodation through behavioral methods. Finally attempts will be made to induce myopia through distortion of the visual input without lid closure or corneal opacification. This will be done by raising monkeys with a) translucent occluders of known light transmittence and b) positive lenses which prevent distinct vision without attenuating light.

该项目的主要目标是阐明其机制