EXPERIMENTAL MYOPIA IN PRIMATES

本项目的主要目标是阐明 负责轴性近视的发生，并制定程序， 治疗和/或预防疾病。 猕猴将被用作 动物模型，因为新生儿眼睑闭合或角膜混浊产生 轴性近视（-4D至-13D）和特征性眼底改变。 以来 中枢神经系统在发育过程中起着重要作用。 阻断传入和传出通路对近视眼的影响 眼睑闭合性近视将通过以下颅内切片进行研究：（1） 视神经，（2）三叉神经，和（3）眼神经。 先前 研究表明，阿托品给药可预防M. arctoides，而M.穆拉塔;住宿的作用将进一步 通过（1）去除睫状神经节，（2）电 睫状神经节的刺激，和（3）通过 行为方法 最后，将尝试通过以下方法诱导近视： 没有眼睑闭合或角膜的视觉输入失真 不透明化 这将通过饲养猴子来完成a）半透明的 具有已知透光率的遮光器和B）正透镜 清晰的视觉而不减弱光线。

The main objectives of this project are to elucidate the mechanisms responsible for the genesis of axial myopia, and to develop procedures to treat and/or prevent the condition. The Macaque monkey will be used as an animal model because neonatal lid closure or corneal opacification produces axial myopia (-4D to -13 D) and characteristic fundus changes. Since the central nervous system plays an important role in the development of the myopia the effects of interrupting afferent and efferent pathways on the lid-closure myopia will be investigated by intracranial section of (1) the optic nerve, (2) the trigeminal nerve, and (3) oculomotor nerves. Previous work indicated that atropine administration prevents axial myopia in M. arctoides but not in M. mulatta; the role of accomodation will be further investigated by (1) removal of the ciliary ganglion, (2) electrical stimulation of the ciliary ganglion, and (3) forced accomodation through behavioral methods. Finally attempts will be made to induce myopia through distortion of the visual input without lid closure or corneal opacification. This will be done by raising monkeys with a) translucent occluders of known light transmittence and b) positive lenses which prevent distinct vision without attenuating light.