EXPERIMENTAL MYOPIA IN PRIMATES

灵长类动物的实验性近视

• 批准号: 3260205
• 负责人: TORSTEN N. WIESEL
• 金额: $ 19.33万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3260205
• 关键词: Macaca; Macaca mulatta; amacrine cells; central nervous system; extracellular matrix; eye accommodation; glia; histochemistry /cytochemistry; histopathology; immunochemistry; myopia; neurogenesis; neuropeptides; newborn animals; radioimmunoassay; tissue /cell culture; vasoactive intestinal peptide; visual deprivation; visual pathways; vitreous body

The objective of this study is to clarify the mechanisms responsible for the genesis of myopia and to develop procedures to prevent this condition. We have shown that surgical lid fusion in neonatal macaque monkeys causes an axial length myopia that is very similar to the human refractive error. In the rhesus macaque, elongation of the eye is primarily caused by disruption of the control of eye growth that is exerted by the retina. In contrast, eye elongation in the stump-tailed macaque is mainly due to the central nervous system through excessive accommodation. The application is concerned with (a) identification of the molecule/s released by the retina that modulate eye growth in the rhesus macaque and testing their effects both in vivo and in vitro; (b) inducing myopia in stump-tailed macaques by forcing the animal to accommodate through behavioral control; (c) assessing the relative contribution of the retina and central nervous system to the pathogenesis of lid-suture myopia in these two primate species.

本研究的目的是阐明负责 近视的成因，并制定程序，以防止这种情况。 我们已经证明，新生猕猴的眼睑融合手术会导致 一种与人类屈光不正非常相似的眼轴长度近视。 在恒河猴中，眼睛的伸长主要是由 视网膜对眼睛生长的控制受到破坏。 在 相比之下，短尾猕猴的眼睛伸长主要是由于 中枢神经系统通过过度调节。 应用程序 涉及（a）识别由视网膜释放的分子 来调节恒河猴眼睛的生长并测试它们的效果 （B）在短尾猕猴中诱导近视， 通过行为控制迫使动物适应;（c）评估 视网膜和中枢神经系统的相对贡献， 这两种灵长类动物眼睑缝合性近视的发病机制。