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EYE MOVEMENTS, RETINAL ACUITY AND MACULAR DISEASE

眼球运动、视网膜视力和黄斑疾病

基本信息

批准号：
3259223
负责人：
STEPHEN G WHITTAKER
金额：
$ 5.72万
依托单位：
SALUS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-04-01 至 1986-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3259223
关键词：
aging eye movements human subject retina degeneration retina disorder vision disorders vision tests visual feedback visual photosensitivity

项目摘要

Abstract: Basic research on normally sighted individuals and the experience of low vision practitioners together strongly suggest that secondary effects of maculopathies are eye instability and poor gaze control. These secondary problems would then contribute substantially to the clinically observed loss in visual acuity and functional loss of reading skills. Yet eye movements of patients with maculopathies have never been recorded accurately. It is critical to separate loss in acuity due to retinal dysfunction from acuity loss due to eye movements in order to: 1) develop effective rehabilitiation protocol and 2) describe retinal dysfunction associated with certain pathologies. To address these problems, experiments are proposed to: 1) measure grating acuity at various retinal regions with an image stabilization system and determine a region of "optimum" acuity, 2) perform a normative study of eye movements as they relate to retinal acuity loss, 3) determine the extent that functional acuity can be improved by using biofeedback training to modify viewing angle so that targets are imaged in a region of "optimum" acuity, and; 4) measure spatial contrast sensitivity utilizing a procedure that is minimally affected by eye movements. These studies will initial by focus on patients with diseases affecting primarily choroid, Bruch's membrane or pigment epithelium such as senile macular degeneration and later study, as distinct categories, patients with sensory retinal disease and vitreous - retinal interface disease.

文摘：视力正常者的基础研究低视力从业者的经验有力地表明黄斑病变的次要影响是眼睛不稳定和凝视不良。控制力。这些次要问题将极大地促进视力和功能丧失的临床观察阅读技巧。然而，黄斑病变患者的眼球运动从未被准确地记录下来。将视力下降分开是至关重要的因视网膜功能障碍而致视力减退的依次眼球运动目的：1)制定有效的康复方案；2)描述视网膜与某些病理有关的功能障碍。要解决这些问题针对存在的问题，提出了以下实验方案：1)测量不同条件下的光栅锐度视网膜区域使用图像稳定系统并确定区域最佳视力，2)对眼球运动进行标准化研究与视网膜视力丧失有关，3)决定功能的程度可以通过使用生物反馈训练来修改视觉来提高视力角度，以使目标被成像在具有最佳锐度的区域，以及；4) 使用以下程序测量空间对比敏感度受眼球运动的影响最小。这些研究将按重点进行。对于主要影响脉络膜、布鲁赫膜或色素上皮如老年性黄斑变性及以后的研究，如不同的类别，视网膜感觉性疾病和玻璃体- 视网膜界面病。