18-BTT: A PATHWAY TO THE EXPLOITATION OF EPIGENETIC VARIATION IN UK, US AND INTERNATIONAL BREEDING PROGRAMMES

18-BTT：英国、美国和国际育种计划利用表观遗传变异的途径

• 批准号: BB/S020942/1
• 负责人: Anthony Hall
• 金额: $ 28.2万
• 依托单位: Earlham Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FS020942%2F1
• 关键词: 18; BTT; PATHWAY; EXPLOITATION; EPIGENETIC

Epigenetic modification represents a potential source of variation that can be used in breeding programmes, contributing to trait variation. In wheat, we have evidence for wide spread and stable epigenetic variation across global landraces. However, this represents a source of variation that has not to date impacted breeding programmes. In this project we aim to accelerate the translation of this basic knowledge, investigating variation in DNA methylation over a set of agronomically important genes across a panel of UK, US and CIMMYT derived wheat germplasm. This will uncover important information about epigenetic inheritance, stability and its role in adaptation. We will develop an enabling technology for breeders to track epi-alleles. We will use this technology to track epi-alleles that we identify in genes controlling agriculturally important traits and associate them with phenotypic changes.

表观遗传修饰是一种潜在的变异来源，可用于育种计划，从而导致性状变异。在小麦中，我们有证据表明全球地方品种的表观遗传变异广泛传播且稳定。然而，这代表了迄今为止尚未影响育种计划的变异来源。在这个项目中，我们的目标是加速这一基础知识的转化，研究英国、美国和 CIMMYT 小麦种质中一组重要农艺基因的 DNA 甲基化变异。这将揭示有关表观遗传、稳定性及其在适应中的作用的重要信息。我们将为育种者开发一种追踪表观等位基因的技术。我们将使用这项技术来追踪我们在控制农业重要性状的基因中识别的表观等位基因，并将它们与表型变化联系起来。

项目成果

Introgressions lead to reference bias in wheat RNA-Seq analysis

基因渗入导致小麦 RNA-Seq 分析中的参考偏差

• DOI: 10.1101/2023.10.04.560829
• 发表时间: 2023
• 作者: Coombes B