EXPERIMENTAL MYOPIA IN PRIMATES

这个项目的主要目标是阐明这些机制 对轴性近视的发生负责，并开发程序来 治疗和/或预防这种情况。猕猴将被用作 因新生儿眼睑闭合或角膜混浊而产生的动物模型 轴性近视(-4D~-13D)和特征性眼底改变。自.以来 中枢神经系统在糖尿病的发生发展中起着重要作用。 近视的传入和传出通路阻断对近视的影响 闭眼性近视将通过(1)的颅内切片进行调查 视神经，(2)三叉神经，(3)动眼神经。上一首 研究表明，使用阿托品可以预防M。 而不是在M.Mulatta中；调节的作用将进一步 通过(1)切除睫状神经节，(2)电检查 刺激睫状神经节，以及(3)通过 行为方法。最后，将尝试通过以下方法诱导近视 视觉输入失真而不闭合眼睑或角膜 混浊。这将通过饲养猴子来实现)半透明 已知透光性的遮盖物和b)防止 清晰的视觉而不会减弱光线。

The main objectives of this project are to elucidate the mechanisms responsible for the genesis of axial myopia, and to develop procedures to treat and/or prevent the condition. The Macaque monkey will be used as an animal model because neonatal lid closure or corneal opacification produces axial myopia (-4D to -13 D) and characteristic fundus changes. Since the central nervous system plays an important role in the development of the myopia the effects of interrupting afferent and efferent pathways on the lid-closure myopia will be investigated by intracranial section of (1) the optic nerve, (2) the trigeminal nerve, and (3) oculomotor nerves. Previous work indicated that atropine administration prevents axial myopia in M. arctoides but not in M. mulatta; the role of accomodation will be further investigated by (1) removal of the ciliary ganglion, (2) electrical stimulation of the ciliary ganglion, and (3) forced accomodation through behavioral methods. Finally attempts will be made to induce myopia through distortion of the visual input without lid closure or corneal opacification. This will be done by raising monkeys with a) translucent occluders of known light transmittence and b) positive lenses which prevent distinct vision without attenuating light.