Bioactive terpenoids as high performance ingredients for industry

生物活性萜类化合物作为高性能工业成分

• 批准号: BB/Y003217/1
• 负责人: Ian Graham
• 金额: $ 88.75万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FY003217%2F1
• 关键词: Bioactive; terpenoids; performance; ingredients; industry

For the UK to achieve its Net Zero targets there is an urgent need across industrial sectors to replace the reliance on petrochemical based feedstocks with sustainable bio-based feedstock. Croda is a UK based multinational company and global leader in high performance ingredients and technologies that are found in some of the most successful brands in the world across a wide range of markets including Personal, Health and Crop Care. Croda has recently undertaken an Executive Committee level product portfolio review and identified a need to focus innovation activities upon industrial biotechnology as a route to sustainable and biobased ingredients across a broad range of areas. Terpenoids represent one of the largest and most diverse classes of natural products in the world, providing an array of functionalities for different industry sectors ranging from flavour and fragrance to human health and personal care. The Graham laboratory at the University of York is world leading in the discovery and development of different classes of terpenoids from plants and have recently been collaborating with Croda to explore the potential of using these to replace petrochemical derived products in the company's portfolio of ingredients being supplied across a range of industrial sectors. Based on proof of concept work, it is clear there is huge potential. The challenge is that many of these terpene based natural products are not available at commercial scale as they are currently only available in relatively small amounts from the plants that produce them. This project will address this challenge by establishing the biosynthetic route to selected terpenoids that perform in Croda's proprietary platforms and by using a combination of synthetic/engineering biology and industrial biotechnology develop new production platforms that will allow commercial scale-up and development of new biobased products. Croda already have expertise in fermentation based scale-up in so called heterologous host platforms that will complement the gene discovery and laboratory scale engineering of host platforms that will be performed at the University of York. Early leads have already been identified for the Crop Care sector which could have a major impact on the sustainability of agriculture.

英国要实现净零排放目标，迫切需要各工业部门用可持续的生物基原料取代对石化原料的依赖。禾大是一家总部位于英国的跨国公司，是高性能成分和技术的全球领导者，这些成分和技术在包括个人、健康和作物护理在内的广泛市场上的一些世界上最成功的品牌中被发现。禾大最近进行了一次执行委员会级别的产品组合审查，并确定需要将创新活动集中在工业生物技术上，作为在广泛领域实现可持续和生物基成分的途径。萜类化合物代表了世界上最大和最多样化的天然产品类别之一，为不同的工业部门提供了一系列功能，从香精香料到人类健康和个人护理。约克大学的格雷厄姆实验室在发现和开发植物中不同类别的萜类化合物方面处于世界领先地位，最近与禾大合作，探索使用这些化合物替代公司成分组合中的石化衍生产品的潜力，这些成分供应给一系列工业部门。基于概念验证工作，很明显有巨大的潜力。挑战在于，许多这些基于萜烯的天然产品不能以商业规模获得，因为它们目前仅以相对少量从生产它们的植物中获得。该项目将通过建立在禾大专有平台上进行的特定萜类化合物的生物合成路线来应对这一挑战，并通过使用合成/工程生物学和工业生物技术的组合来开发新的生产平台，从而实现商业规模扩大和开发新的生物基产品。禾大已经拥有在所谓的异源宿主平台中基于发酵的规模放大的专业知识，这将补充将在约克大学进行的宿主平台的基因发现和实验室规模工程。作物护理行业的早期领导者已经确定，这可能对农业的可持续性产生重大影响。