STUDIES OF MAMMALIAN OOCYTES

哺乳动物卵母细胞的研究

• 批准号: 3315880
• 负责人: GEORGIANA M JAGIELLO
• 金额: $ 20.87万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3315880
• 关键词: DNA methylation; cell differentiation; cell nucleus; egg /ovum; electron microscopy; gene expression; human tissue; meiosis; methylation; microscopy; mitochondrial DNA; natural gene amplification; oogenesis; sex chromosomes; sperm; spermatogenesis

The work in these laboratories has for some years focused on mammalian meiosis, with particular emphasis on oogenesis. We have been concerned with the cytologic, biochemical, ultrastructural and hormonal aspects of this process in mammals, particularly human. This attention stems from the fundamental interest in the causes of abnormal progeny in the human, particularly the progeny who result from numerical or structural abnormalities in the germ cell genome. The present application takes a new direction built upon the body of data and hypotheses which hane resulted from this interest. The application process to examine (1) the characteristics of fetal mouse oogonia proceeding toward meiosis (2) chemical and conformational modifications of nuclei and mitochondria of oogeneis and spermatogenesis and (3) the model that distortion of pairing of homologues by microtubule inhibiting agents affects recombination. These studies bring together the biology of germ cell development and the simultaneous changes in the nucleus.

多年来，这些实验室的工作一直集中在哺乳动物身上