REPRODUCTIVE BIOCHEMISTRY AND MEDICINE

特殊人口研究中心在这份申请中提出， 目标是一个假设和现代生物医学技术的综合， 从分子生物学到生殖科学的连续学科 到生理学。原则、资源和专门知识的紧密结合 是根本性的。这项工作包括十个项目，分为两个 神经科学和早期发展的广泛类别;我，一项研究， TGF-β，II，哺乳动物精子发生的分析; III， hap 26在果蝇中的表达，IV，GnRH脉冲的研究 灵长类中的发生器，V，生长的产前表达的研究 因子基因和受体; VI，恒河猴GnRH网络的研究 脑神经解剖学方法; VII，胎盘CRH分析， 怀孕狒狒，八，类固醇/生长因子的实验， 神经发育; IX，性类固醇调节脑POMC的研究， LH和X，哺乳动物中原癌基因表达的分析 配子发生组织了五个生物医学核心，以加快技术 使用灵长类动物群，分子细胞学/组织学技术， 类固醇和蛋白质、细胞和杂交放射免疫测定 培养和分子生物学设施。

The Specialized Population Research Center proposed in this application targets a synthesis of hypotheses and modern biomedical techniques in a continuum of disciplines in reproductive sciences from molecular biology to physiology. Close integration of principles, resources and expertise is fundamental. The work includes ten projects which fall into the two broad categories of neuroscience and early development; I, a study of TGF-beta, II, an analyses of mammalian spermatogenesis; III, a study of hap26 expression in Drosophila, IV, the study of the GnRH pulse generator in primates, V, a study of the prenatal expression of growth factor genes and receptors; VI, a study of GnRH networks in the rhesus brain by neuroanatomical methods,; VII, analysis of placental CRH in pregnant baboons, VIII, experiments with steroid/growth factors in neurodevelopment; IX, study of sex steroid regulation of brain POMC and LH and X, an analysis of proto-oncogene expression during mammalian gametogenesis. Five biomedical cores are organized to expedite technical usage of a primate colony, molecular cytology/histology techniques, radioimmunoassay of steroids and proteins, cell and hybridization culture, and a molecular biology facility.