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Microchemical single droplet reaction analysis by online cavity ring-down spectroscopy

在线腔衰荡光谱微化学单液滴反应分析

基本信息

批准号：
EP/G027951/1
负责人：
Joao Cabral
金额：
$ 22.2万
依托单位：
Imperial College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FG027951%2F1
关键词：
Microchemical single droplet reaction analysis

项目摘要

Microfluidics provides an exceptional environment for the generation of controlled droplet dispersions and their manipulation in prescribed flow fields. The spatio-temporal correspondence between microchannel position and reaction 'time' permits the study of kinetics of (chemical and physical) processes with unprecedented time resolution and dynamic range. Further, the combination of the small volumes of droplet 'reactors' and the precise formulation of their composition opens vast possibilities in chemical synthesis, including screening, discovery and optimisation. Monitoring reactions in real-time with non-invasive probes remains, hitherto, a major shortcoming of microchemical reactors due to the minute sample volumes (pL-nL) and fast travel speeds (1-1000 mm/s). This proposal seeks to develop, implement and validate a novel experimental approach to monitor microchemical reactions in real-time by coupling, for the first time, cavity ring-down spectroscopy and solvent-resistant microfabrication. This approach will permit the online study of model catalytic reactions, with unprecedented reproducibility and flow control. Cavity ring-down spectroscopy will permit the analysis of pL volumes, effectively eliminating the restriction of path length in microchannels, with nanosecond to microsecond time resolution, compatible with microreaction drops. In particular, we will elucidate individual and global reaction population outcomes and the effect of mixing and flow, with spatiotemporal resolution. This approach is applicable to a range of organic chemical reactions and, for this work, we will focus on selected model systems (detailed below) of fundamental and industrial relevance.

微流体技术为受控液滴分散的产生及其在规定流场中的操纵提供了一个特殊的环境。微通道位置和反应时间之间的时空对应关系允许研究具有前所未有的时间分辨率和动态范围的（化学和物理）过程的动力学。此外，小体积液滴“反应器”与其组成的精确配方相结合，为化学合成（包括筛选、发现和优化）提供了巨大的可能性。迄今为止，由于微小的样品体积（pL-nL）和快速的行进速度（1-1000 mm/s），用非侵入式探针实时监测反应仍然是微化学反应器的主要缺点。该提案旨在开发，实施和验证一种新的实验方法，以实时监测微化学反应，耦合，第一次，腔衰荡光谱和耐溶剂微加工。这种方法将允许对模型催化反应进行在线研究，具有前所未有的重现性和流量控制。腔衰荡光谱将允许分析pL体积，有效地消除了微通道中路径长度的限制，具有纳秒到微秒的时间分辨率，与微反应液滴兼容。特别是，我们将阐明个人和全球的反应人口的结果和混合和流动的影响，与时空分辨率。这种方法适用于一系列有机化学反应，对于这项工作，我们将专注于选定的基本和工业相关的模型系统（下文详述）。