Micro-Plasma Technology for Controlling Cellular Interactions on Medical Implants
用于控制医疗植入物上细胞相互作用的微等离子体技术
基本信息
- 批准号:EP/G048444/1
- 负责人:
- 金额:$ 74.04万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2009
- 资助国家:英国
- 起止时间:2009 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Plasma discharges are an ideal tool to modify polymeric surfaces used in biomedical research, introducing specific elements or functional groups onto the surface. In particular, plasma processes can transfer cell-adhesive or cell-repulsive groups over small domains, often through the use of masks.One major aim of this study will be to develop new atmospheric pressure plasmas (micro-plasma jets) as platforms to create chemically defined bio-surfaces on the micron scale without the need for masks. Atmospheric pressure plasmas have the advantage over vacuum-based techniques in that the plasmas themselves can be scaled to a size approaching cellular dimensions, offering novel applications in medicine and biology, and are cheap, portable and very efficient in terms of power consumption. The micro-plasma jets will operate in number of different gases and polymerisable monomers and chemical features with specific functionality down to 50 microns dimensions will be defined on a range of polymeric surfaces. The technology will be directly applied to the surface modification of intraocular lens IOL implants to study and control the interaction of human epithelial cells (LEC) on the lens. The adhesion, proliferation and migration of LECs on chemically defined surfaces and gradients will be of prime importance in assessing the technology as a tool for bio-materials engineering. The chemical and physical nature of the polymerized surfaces (analysed using XPS and other surface analytical tools) will be correlated to measurements of the plasma jet composition and also the cell-surface interactions.
等离子体放电是生物医学研究中聚合物表面改性的理想工具,可以在表面引入特定的元素或官能团。特别是,等离子体工艺可以转移细胞粘附或细胞排斥基团在小域,往往通过使用masks.One的主要目的,这项研究将是开发新的大气压等离子体(微等离子体射流)作为平台,创建化学定义的生物表面上的微米尺度,而不需要口罩。大气压等离子体具有优于基于真空的技术的优点,因为等离子体本身可以缩放到接近细胞尺寸的尺寸,在医学和生物学中提供新的应用,并且便宜、便携并且在功耗方面非常有效。微等离子体射流将在许多不同的气体和可聚合单体中操作,并且将在一系列聚合物表面上限定具有低至50微米尺寸的特定功能的化学特征。该技术将直接应用于人工透镜IOL植入物的表面改性,以研究和控制人上皮细胞(LEC)在透镜上的相互作用。LEC在化学定义的表面和梯度上的粘附、增殖和迁移将是评估该技术作为生物材料工程工具的首要问题。聚合表面的化学和物理性质(使用XPS和其他表面分析工具分析)将与等离子体射流组合物的测量以及细胞-表面相互作用相关。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Interaction of multiple plasma plumes in an atmospheric pressure plasma jet array
- DOI:10.1088/0022-3727/46/5/052001
- 发表时间:2013-02-06
- 期刊:
- 影响因子:3.4
- 作者:Ghasemi, M.;Olszewski, P.;Walsh, J. L.
- 通讯作者:Walsh, J. L.
Heavy Ion Formation in Plasma Jet Polymerization of Heptylamine at Atmospheric Pressure Heavy Ion Formation in Plasma Jet Polymerization
大气压下庚胺等离子喷射聚合中重离子的形成 等离子喷射聚合中重离子的形成
- DOI:10.1002/ppap.201300042
- 发表时间:2013
- 期刊:
- 影响因子:3.5
- 作者:Oh J
- 通讯作者:Oh J
Observation of discharge and plasma bullet formation in capillary dielectric barrier micro-discharges
毛细管介质阻挡微放电中放电和等离子体弹形成的观察
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:Jun-Seok Oh James W Bradley (Co-Author)
- 通讯作者:Jun-Seok Oh James W Bradley (Co-Author)
Polystyrene Surface Modification for Localized Cell Culture Using a Capillary Dielectric Barrier Discharge Atmospheric- P ressure Microplasma Jet
使用毛细管介质阻挡放电常压微等离子体喷射进行局部细胞培养的聚苯乙烯表面改性
- DOI:10.1002/ppap.201300052
- 发表时间:2013
- 期刊:
- 影响因子:3.5
- 作者:Doherty K
- 通讯作者:Doherty K
Plasma polymerization using helium atmospheric-pressure plasma jet with heptylamine monomer
- DOI:10.1002/ppap.201800185
- 发表时间:2019-04-01
- 期刊:
- 影响因子:3.5
- 作者:Doherty, Kyle G.;Oh, Jun-Seok;Williams, Rachel L.
- 通讯作者:Williams, Rachel L.
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James Bradley其他文献
Histoplasmosis Around the World: A Global Perspective on Presentation, Virulence Factors, and Treatment of Histoplasmosis.
世界各地的组织胞浆菌病:组织胞浆菌病的表现、毒力因素和治疗的全球视角。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:3.1
- 作者:
Pooja Gandhi;randon Hebert;Angelica Yun;James Bradley;Bogdan Moldoveanu - 通讯作者:
Bogdan Moldoveanu
Multicenter, Prospective, Nonrandomized Study of Bipolar RF for the Treatment of Articular Cartilage Defects of the Knee (SS-20)
- DOI:
10.1016/s0749-8063(07)60020-6 - 发表时间:
2002-05-01 - 期刊:
- 影响因子:
- 作者:
Francois Antounian;Champ Baker;James Bradley;George Branche;Alexander Glogau;Jonathon Greenleaf;Lawrence Lemak;Frank Pettrone;Dean Walker - 通讯作者:
Dean Walker
In situ neutron diffraction studies of operating MGA thermal storage materials
运行中 MGA 蓄热材料的原位中子衍射研究
- DOI:
10.1051/rees/2017023 - 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
H. Sugo;E. Kisi;James Bradley;T. Fiedler;V. Luzin - 通讯作者:
V. Luzin
Risk assessment for aortic dissection in Turner syndrome: The role of the aortic growth rate
特纳综合征主动脉夹层的风险评估:主动脉生长率的作用
- DOI:
10.1111/cen.15017 - 发表时间:
2024 - 期刊:
- 影响因子:3.2
- 作者:
M. Calanchini;James Bradley;Fiona McMillan;Saul G Myerson;Andrea Fabbri;Helen E Turner;Elizabeth Orchard - 通讯作者:
Elizabeth Orchard
Notetaking, Working Memory, and Learning in Principles of Economics
经济学原理中的笔记、工作记忆和学习
- DOI:
10.1080/00220485.1995.10844880 - 发表时间:
1995 - 期刊:
- 影响因子:0.9
- 作者:
E. Cohn;S. Cohn;James Bradley - 通讯作者:
James Bradley
James Bradley的其他文献
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{{ truncateString('James Bradley', 18)}}的其他基金
A novel coating technology based upon polyatomic ions from plasma
基于等离子体多原子离子的新型涂层技术
- 批准号:
EP/S005153/1 - 财政年份:2019
- 资助金额:
$ 74.04万 - 项目类别:
Research Grant
Ambient Processing of Polymeric Web: Advanced Diagnostics and Applications
聚合物纤维网的环境处理:高级诊断和应用
- 批准号:
EP/K016202/1 - 财政年份:2013
- 资助金额:
$ 74.04万 - 项目类别:
Research Grant
Micro-PADI sources for applications in 2-D chemical imaging
用于二维化学成像应用的 Micro-PADI 源
- 批准号:
EP/I028722/1 - 财政年份:2011
- 资助金额:
$ 74.04万 - 项目类别:
Research Grant
A New Route to high-Performance Functional Films on Polymeric Web
聚合物网上高性能功能薄膜的新途径
- 批准号:
EP/F004605/1 - 财政年份:2007
- 资助金额:
$ 74.04万 - 项目类别:
Research Grant
The Study of Magnetized Electronegative Depositing Plasmas
磁化负电沉积等离子体的研究
- 批准号:
EP/E035183/1 - 财政年份:2007
- 资助金额:
$ 74.04万 - 项目类别:
Research Grant
Dual Source Pulsed Plasmas for the Production of Ultra-High Performance Coatings
用于生产超高性能涂层的双源脉冲等离子体
- 批准号:
EP/E003397/1 - 财政年份:2007
- 资助金额:
$ 74.04万 - 项目类别:
Research Grant
Scale-up feasibility of plasma deposition in 3D tissue engineering scaffolds
3D 组织工程支架中等离子体沉积放大的可行性
- 批准号:
EP/E010962/1 - 财政年份:2006
- 资助金额:
$ 74.04万 - 项目类别:
Research Grant
3rd INTERACT travel grant: Starting point for collaboration with a Japanese network in microplasmas
第三次 INTERACT 旅行补助金:与日本微等离子体网络合作的起点
- 批准号:
EP/D038847/1 - 财政年份:2006
- 资助金额:
$ 74.04万 - 项目类别:
Research Grant
Reorganization and Computerization of the Robert S. Peabody Museum of Archaeological Collections
罗伯特·S·皮博迪考古收藏博物馆的重组和计算机化
- 批准号:
9307572 - 财政年份:1993
- 资助金额:
$ 74.04万 - 项目类别:
Standard Grant
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