INFANT HEAT LOSS DETERMINED BY INFRARED THERMOGRAPHY

这项研究的长期目标是提供有价值的 以下婴儿热量损失和能量消耗的信息 各种环境和临床条件，目标是 改善新生儿管理，降低发病率和死亡率。 本研究的具体目标是：（1）对红外光谱进行改性， 热成像作为一种非侵入性，即时和准确的新方法， 测量热量损失，从而测量婴儿的能量消耗，（2） 通过与传统的红外热成像方法进行比较， 确定婴儿能量消耗的方法， 间接量热法，以及（3）确定能量差异 在子宫内暴露于药物滥用的婴儿中发现了支出， 新生儿期和前三个月未接触的婴儿 几个月的生活。 为了实现这些目标，设计了三个实验 目标。 首先，正常新生儿（n=25），低出生体重（n=15），和非常 低出生体重婴儿（n=10）将使用红外线进行研究 热成像法来确定能量消耗，以及辐射，对流， 蒸发和传导热损失。 热损失方程为 修改以计算不同出生婴儿的能量消耗 体重和胎龄。 第二，能源消耗将 正常出生体重（n=10），低出生体重孵育 （n=10）和未孵育（n=10），以及孵育极低出生体重 （n=10）通过同步红外热成像和间接 量热法。 这项研究将确定红外的有效性 热成像来量化这些婴儿的能量消耗， 典型的住院婴儿群体。 第三，能源 将确定吸毒母亲所生婴儿的支出 （n-20）在出生后0、4、8和12周。 能源消耗将 在无药物母亲所生的匹配对照婴儿中测定（n--20） 根据出生体重与药物暴露婴儿配对， 胎龄组。 红外热成像可能是一个有用的临床 和研究婴儿热量散失的研究工具。 它的使用可能会导致 更好的婴儿护理，以及更准确的预测婴儿 能量消耗和体温调节能力。 使用这个新的 一项信息性研究中的技术将确定暴露于药物的婴儿 显示能量消耗的变化，这是一个未识别的重要 临床问题

The long term objective of this research is to provide valuable information on heat loss and energy expenditure in infants under a variety of environmental and clinical conditions, with the goal of improving neonatal management and decreasing morbidity and mortality. The specific aims of this research are (1) to modify infrared thermography as a non-invasive, instant and accurate new method of measuring heat loss, and thus energy expenditure in infants, (2) to validate the new method, infrared thermography, by comparing it with an established method of determining energy expenditure in infants, indirect calorimetry, and (3) to determine if differences in energy expenditure are found in infants exposed to drug abuse in utero vs. unexposed infants both during the neonatal period and the first three months of life. Three experiments have been designed to achieve these aims. First, normal newborns (n=25), low birth weight (n=15), and very low birth weight (n=10) infants will be studied using infrared thermography to determine energy expenditure, and radiant, convective, evaporative and conductive heat losses. Heat loss equations will be modified to calculate energy expenditure in infants of varying birth weight and gestational age. Second, energy expenditure will be determined in normal birth weight (n=10), low birth weight incubated (n=10) and non-incubated (n=10), and incubated very low birth weight (n=10) infants by concurrent infrared thermography and indirect calorimetry. This study will determine the validity of infrared thermography to quantify energy expenditure in such infants, which are typical of the hospitalized infant population. Third, energy expenditure will be determined in infants born to drug abusing mothers (n--20) at 0, 4, 8 and 12 weeks of life. Energy expenditure will be determined in matched control infants born to drug-free mothers (n--20) paired with drug-exposed infants on the basis of birth weight and gestational age group. Infrared thermography may be a useful clinical and research tool for studying infant heat loss. Its use may result in better infant care, as well as more accurate predictions of infant energy expenditure and thermoregulatory ability. The use of this new technique in an informative study will determine if drug-exposed infants exhibit changes in energy expenditure, an unidentified and important clinical problem.